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  1. The skin temperature (Tm) of the orofacial area influences orofacial functions and is related to the blood flow (BF). Marked increases in BF mediated by parasympathetic vasodilation may be important for orofacial...

    Authors: Hanako Ohke, Toshiya Sato, Kohei Mito, Makoto Terumitsu and Hisayoshi Ishii

    Citation: The Journal of Physiological Sciences 2020 70:22

    Content type: Original Paper

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  2. Blood pressure response to head-up tilt (HUT) in 7 healthy subjects and 9 patients before and after coronary artery bypass grafting (CABG) was measured during supine and 15-min 60° HUT. Stroke volume (SV) and ...

    Authors: Shinnosuke Hori, Yoshi-ichiro Kamijo, Mitsuru Yuzaki, Tetsuya Kawabe, Kohei Minami, Yasunori Umemoto, Mao Yokoyama, Hiroyasu Uenishi, Yoshiharu Nishimura, Ken Kouda, Yukio Mikami and Fumihiro Tajima

    Citation: The Journal of Physiological Sciences 2020 70:21

    Content type: Original Paper

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  3. The homeobox-containing gene Csx/Nkx2.5 codes several cardiac transcription factors and plays a critical role in early cardiogenesis. We investigated the effect of Csx/Nkx2.5 on the expression of cardiac ion c...

    Authors: Tomoko Uchino, Ming-Qi Zheng, Yan Wang and Katsushige Ono

    Citation: The Journal of Physiological Sciences 2020 70:20

    Content type: Original Paper

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  4. High-fat diet (HFD) can induce deficits in neural function, oxidative stress, and decrease hippocampal neurogenesis. Hypericum (H.) scabrum extract (Ext) contains compounds that could treat neurological disorders...

    Authors: Ghazaleh Omidi, Arezoo Rezvani-Kamran, Ahmad Ganji, Somayeh Komaki, Farshid Etaee, Masoumeh Asadbegi and Alireza Komaki

    Citation: The Journal of Physiological Sciences 2020 70:19

    Content type: Original Paper

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  5. Class II phosphatidylinositol 3-kinases (PI3K), PI3K-C2α and PI3K-C2β, are involved in cellular processes including endocytosis, cilia formation and autophagy. However, the role of PI3K-C2α and PI3K-C2β at the...

    Authors: Shahidul Islam, Kazuaki Yoshioka, Sho Aki, Kazuhiro Ishimaru, Hiroki Yamada, Noriko Takuwa and Yoh Takuwa

    Citation: The Journal of Physiological Sciences 2020 70:18

    Content type: Original Paper

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  6. The peripheral vestibular organs are sensors for linear acceleration (gravity and head tilt) and rotation. Further, they regulate various body functions, including body stability, ocular movement, autonomic ne...

    Authors: Hironobu Morita, Hiroshi Kaji, Yoichi Ueta and Chikara Abe

    Citation: The Journal of Physiological Sciences 2020 70:17

    Content type: Review

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  7. Respiratory disturbances present in Parkinson’s disease (PD) are not well understood. Thus, studies in animal models aimed to link brain dopamine (DA) deficits with respiratory impairment are needed. Adult Wis...

    Authors: Kryspin Andrzejewski, Monika Jampolska, Małgorzata Zaremba, Ilona Joniec-Maciejak, Paweł M. Boguszewski and Katarzyna Kaczyńska

    Citation: The Journal of Physiological Sciences 2020 70:16

    Content type: Original Paper

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  8. The purpose of the present study was to assess the effect of different water immersion temperatures on handgrip performance and haemodynamic changes in the forearm flexors of males and females. Twenty-nine roc...

    Authors: Jiří Baláš, Jan Kodejška, Dominika Krupková and David Giles

    Citation: The Journal of Physiological Sciences 2020 70:13

    Content type: Original Paper

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  9. Experiments on animal hearts (rat, rabbit, guinea pig, etc.) have demonstrated that mechano-calcium feedback (MCF) and mechano-electric feedback (MEF) are very important for myocardial self-regulation because ...

    Authors: Nathalie A. Balakina-Vikulova, Alexander Panfilov, Olga Solovyova and Leonid B. Katsnelson

    Citation: The Journal of Physiological Sciences 2020 70:12

    Content type: Original Paper

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  10. Pathophysiological functions of chloride intracellular channel protein 3 (CLIC3) in human gastric cancer have been unclear. In the tissue microarray analysis using 107 gastric cancer specimens, CLIC3 expressio...

    Authors: Shunsuke Kawai, Takuto Fujii, Takahiro Shimizu, Kenta Sukegawa, Isaya Hashimoto, Tomoyuki Okumura, Takuya Nagata, Hideki Sakai and Tsutomu Fujii

    Citation: The Journal of Physiological Sciences 2020 70:15

    Content type: Original Paper

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  11. Oral administration of donepezil, a centrally acting acetylcholinesterase inhibitor, improves the survival of rats with chronic heart failure (CHF). The mechanisms of cardioprotective effects of donepezil, how...

    Authors: Meihua Li, Can Zheng, Toru Kawada, Masashi Inagaki, Kazunori Uemura and Masaru Sugimachi

    Citation: The Journal of Physiological Sciences 2020 70:11

    Content type: Original Paper

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  12. Exercise has been reported to induce autophagy. We hypothesized that exercise preconditioning (EP)-related autophagy in cardiomyocytes could be attributed to intermittent ischemia–hypoxia, allowing the heart t...

    Authors: Jian-Qi Yuan, Yang Yuan, Shan-Shan Pan and Ke Cai

    Citation: The Journal of Physiological Sciences 2020 70:10

    Content type: Original Paper

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  13. Pulmonary vein (PV) cardiomyocytes have the potential to generate spontaneous activity, in contrast to working myocytes of atria. Different electrophysiological properties underlie the potential automaticity o...

    Authors: Daichi Takagi, Yosuke Okamoto, Takayoshi Ohba, Hiroshi Yamamoto and Kyoichi Ono

    Citation: The Journal of Physiological Sciences 2020 70:6

    Content type: Original Paper

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  14. While our recent studies have suggested that effective acupoints display neurogenic inflammation and can be identified as neurogenic spots (Neuro-Sps), the optimal stimulation conditions and the underlying mec...

    Authors: Joo Hyun Shin, Yu Fan, Do-Hee Kim, Han Byeol Jang, Suchan Chang, Yeonhee Ryu, Jong Han Bae, Sanghag Lee, Bong Hyo Lee, Scott C. Steffensen, Chae Ha Yang and Hee Young Kim

    Citation: The Journal of Physiological Sciences 2020 70:14

    Content type: Original Paper

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  15. We have previously reported that the negative inotropic effects of hyperthermia (42 °C) on left ventricular (LV) mechanoenergetics using the excised, cross-circulated rat heart model. Here, we investigated the...

    Authors: Koji Obata, Hironobu Morita and Miyako Takaki

    Citation: The Journal of Physiological Sciences 2020 70:4

    Content type: Original Paper

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  16. The present study aimed to investigate whether endurance exercise-induced changes in blood plasma composition may lead to adaptations in erythrocytes, skeletal muscle and liver. Forty sedentary rats were rando...

    Authors: Georgios Goutianos, Nikos V. Margaritelis, Theodora Sparopoulou, Aristidis S. Veskoukis, Ioannis S. Vrabas, Vassilis Paschalis, Michalis G. Nikolaidis and Antonios Kyparos

    Citation: The Journal of Physiological Sciences 2020 70:3

    Content type: Original Paper

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  17. Fragrance inhalation of essential oils is widely used in aromatherapy, and it is known to affect blood pressure (BP) and heart rate (HR) via autonomic control of circulation. In this study, we aimed to test th...

    Authors: Eriko Kawai, Ryosuke Takeda, Akemi Ota, Emiko Morita, Daiki Imai, Yuta Suzuki, Hisayo Yokoyama, Shin-ya Ueda, Hidehiro Nakahara, Tadayoshi Miyamoto and Kazunobu Okazaki

    Citation: The Journal of Physiological Sciences 2020 70:2

    Content type: Original Paper

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  18. We hypothesized that cerebral blood flow (CBF) regulation in the posterior circulation differs from that of the anterior circulation during a cold pressor test (CPT) and is accompanied by elevations in arteria...

    Authors: Takuro Washio, Hironori Watanabe and Shigehiko Ogoh

    Citation: The Journal of Physiological Sciences 2020 70:1

    Content type: Original Paper

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  19. Distress vocalizations are fundamental for survival, and both sonic and ultrasonic components of such vocalizations are preserved phylogenetically among many mammals. On this basis, we hypothesized that ultras...

    Authors: Hirokazu Doi, Simone Sulpizio, Gianluca Esposito, Masahiro Katou, Emi Nishina, Mayuko Iriguchi, Manabu Honda, Tsutomu Oohashi, Marc H. Bornstein and Kazuyuki Shinohara

    Citation: The Journal of Physiological Sciences 2019 69:729

    Content type: Original Paper

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  20. Menopause is a risk factor for impaired glucose metabolism. Alternative treatment of estrogen for postmenopausal women is required. The present study was designed to investigate the effects of 5-week endurance...

    Authors: Mizuho Kawakami, Naoko Yokota-Nakagi, Akira Takamata and Keiko Morimoto

    Citation: The Journal of Physiological Sciences 2019 69:723

    Content type: Original Paper

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  21. Hypoglycemia-associated autonomic failure (HAAF) is a serious complication of diabetes which is associated with the absence of physiological homeostatic counter-regulatory mechanisms that are controlled by the...

    Authors: Bashair M. Mussa, Jalal Taneera, Abdul Khader Mohammed, Ankita Srivastava, Debasmita Mukhopadhyay and Nabil Sulaiman

    Citation: The Journal of Physiological Sciences 2019 69:718

    Content type: Original Paper

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  22. An atrial tachyarrhythmias is predominantly triggered by a proarrhythmic activity originate from the pulmonary veins (PV) myocardial sleeves; sympathetic or adrenergic stimulation facilitates PV proarrhythmia....

    Authors: V. M. Potekhina, O. A. Averina, A. A. Razumov, V. S. Kuzmin and L. V. Rozenshtraukh

    Citation: The Journal of Physiological Sciences 2019 69:724

    Content type: Original Paper

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  23. This brief review summarizes the current knowledge on sex differences in baroreflex function, with a major focus on studies in humans. It has been demonstrated that healthy women have blunted cardiovagal baror...

    Authors: Qi Fu and Shigehiko Ogoh

    Citation: The Journal of Physiological Sciences 2019 69:727

    Content type: Review

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  24. The cardiovascular effects of the autonomic nervous system (ANS) are modulated by inputs from peripheral sensors and other brain regions. However, it currently remains unknown whether the manual acupuncture (M...

    Authors: Hidehiro Nakahara, Toru Kawada, Shin-ya Ueda, Eriko Kawai, Hiromi Yamamoto, Masaru Sugimachi and Tadayoshi Miyamoto

    Citation: The Journal of Physiological Sciences 2019 69:728

    Content type: Original Paper

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  25. When choosing the best action from several alternatives, we compare each value that depends on the balance between benefit and cost. Previous studies have shown that animals and humans with low brain serotonin...

    Authors: Fumika Akizawa, Takashi Mizuhiki, Tsuyoshi Setogawa, Mai Takafuji and Munetaka Shidara

    Citation: The Journal of Physiological Sciences 2019 69:725

    Content type: Original Paper

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  26. Increasing evidence demonstrates that electric stimulation has anticonvulsant effects. The present study was undertaken to investigate the effects of mild foot electrical stimulation (MFES) on the development ...

    Authors: Arefe Ghasemi-Dehno, Abolfazl Jand, Monir Abasi-Moghadam, Mehdi Sadegh, Morteza Mousavi-Hasanzadeh and Mohammad Reza Palizvan

    Citation: The Journal of Physiological Sciences 2019 69:726

    Content type: Original Paper

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  27. Mesenchymal stem cells (MSCs) are regarded as unique cells which play an imperative role in the field of regenerative medicine. They are characterized by the self-renewal capacity, multi-lineage differentiatio...

    Authors: Ramada R. Khasawneh, Ejlal Abu-El-Rub, Abdullah Omar Serhan, Bashar Omar Serhan and Hadeel Abu-El-Rub

    Citation: The Journal of Physiological Sciences 2019 69:720

    Content type: Original Paper

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  28. We aimed to identify the neurotransmitters and brain regions involved in exercise efficiency in mice during continuous complicated exercises. Male C57BL/6J mice practiced treadmill running with intermittent ob...

    Authors: Tetsuya Shiuchi, Takuya Masuda, Noriyuki Shimizu, Sachiko Chikahisa and Hiroyoshi Séi

    Citation: The Journal of Physiological Sciences 2019 69:722

    Content type: Original Paper

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  29. To investigate the exercise intensity effects on rats’ memory and learning, animals were divided into control, moderate training (MT), and overtraining (OT) groups. At training last week, learning and memory w...

    Authors: Zahra Jahangiri, Zahra Gholamnezhad, Mahmoud Hosseini, Farimah Beheshti and Narges Kasraie

    Citation: The Journal of Physiological Sciences 2019 69:719

    Content type: Original Paper

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  30. The aim of this study was to investigate the effect of activated ghrelin with dietary octanoic acids or medium-chain triglyceride (MCT) administration to underweight patient with chronic obstructive pulmonary ...

    Authors: Keisuke Miki, Seigo Kitada, Mari Miki, Shu-Ping Hui, Rojeet Shrestha, Kenji Yoshimura, Kazuyuki Tsujino, Hiroyuki Kagawa, Yohei Oshitani, Hiroshi Kida, Ryoji Maekura and Kenji Kangawa

    Citation: The Journal of Physiological Sciences 2019 69:716

    Content type: Original Paper

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  31. Expiratory (E) neurons in the caudal nucleus retroambigualis extend descending spinal axons to the lumbar and sacral spinal cord. Discharge rates of single E neurons were recorded to examine differences in act...

    Authors: Sei-Ichi Sasaki, Ken Muramatsu and Masatoshi Niwa

    Citation: The Journal of Physiological Sciences 2019 69:715

    Content type: Original Paper

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  32. Milk supply and quality during lactation are critical for progeny survival. Maternal tissues and metabolism, influenced by hormonal changes, undergo modification during lactation to sustain breastfeeding. Two ...

    Authors: Gustavo Canul-Medina and Cristina Fernandez-Mejia

    Citation: The Journal of Physiological Sciences 2019 69:714

    Content type: Review

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  33. Diarrhea is a gastrointestinal symptom associated with systemic anaphylaxis and could be induced by increased colonic motility. We determined colonic motility and expulsion by measuring the intracolonic pressu...

    Authors: Tao Zhang, Toshishige Shibamoto, Mamoru Tanida, Yuhichi Kuda, Wei Yang and Yasutaka Kurata

    Citation: The Journal of Physiological Sciences 2019 69:710

    Content type: Original Paper

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  34. In the diabetic brain, hyperglycemia damages the cerebrovasculature and impairs neurovascular crosstalk. Calcitonin gene-related peptide (CGRP) is an important neuropeptide that is active in the vascular syste...

    Authors: Yanjun Guo, Qin Zhang, Huilu Chen, Yixuan Jiang and Ping Gong

    Citation: The Journal of Physiological Sciences 2019 69:708

    Content type: Original Paper

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  35. Motor units are generally recruited from the smallest to the largest following the size principle, while cutaneous stimulation has the potential to affect spinal motor control. We aimed to examine the effects ...

    Authors: Kotaro Tamura, Satoshi Sugita, Tadayuki Tokunaga, Yoshihiko Minegishi and Noriyasu Ota

    Citation: The Journal of Physiological Sciences 2019 69:707

    Content type: Original Paper

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  36. The vestibular system contributes to not only eye movement and posture but also the sympathetic response. Plastic alteration of the vestibulo-sympathetic reflex is induced by hypergravity load; however, the me...

    Authors: Chikara Abe, Yusuke Yamaoka, Yui Maejima, Tomoe Mikami and Hironobu Morita

    Citation: The Journal of Physiological Sciences 2019 69:705

    Content type: Original Paper

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  37. This study determined whether blockade of 5-hydroxytryptamine 2A (5-HT2A) receptors attenuated hyperthermia and tachycardia responses to psychological stress in mice. For this purpose, male mice (C57BL/6N) wer...

    Authors: Vanshika Sinh and Youichirou Ootsuka

    Citation: The Journal of Physiological Sciences 2019 69:703

    Content type: Short Communication

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  38. Exercise has an effect on the reduction of myocardial fibrosis in diabetic rats as previously reported, in which oxidative stress and the TGF-β1/Smad signaling pathway may play key roles. There is little direc...

    Authors: Shi-Qiang Wang, Dan Li and Yang Yuan

    Citation: The Journal of Physiological Sciences 2019 69:696

    Content type: Original Paper

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  39. We investigated the effect of muscle damage and inflammation on electrical resistance and the body composition assessment by using bioimpedance spectroscopy (BIS). Twenty-two subjects completed 30 repetitions ...

    Authors: Keisuke Shiose, Yoko Tanabe, Takahiro Ohnishi and Hideyuki Takahashi

    Citation: The Journal of Physiological Sciences 2019 69:702

    Content type: Original Paper

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  40. Intermittent claudication (IC) is the most common symptom of peripheral arterial disease which significantly deteriorates the quality of life of patients. Exercise training is by far the most effective treatme...

    Authors: Momoko Shiragaki-Ogitani, Keita Kono, Futoshi Nara and Atsushi Aoyagi

    Citation: The Journal of Physiological Sciences 2019 69:701

    Content type: Original Paper

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  41. In congestive heart failure (CHF), while resting parasympathetic activity becomes reduced, parasympathetically-mediated responses to stressors have not been described. This study aimed to (1) elucidate the eff...

    Authors: Satoshi Koba, Ichiro Hisatome and Tatsuo Watanabe

    Citation: The Journal of Physiological Sciences 2019 69:698

    Content type: Original Paper

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  42. Near-infrared spectroscopy (NIRS) has become an increasingly valuable tool to monitor tissue oxygenation (Toxy) in vivo. Observations of changes in the absorption of light with Toxy have been recognized as early ...

    Authors: Takafumi Hamaoka and Kevin K. McCully

    Citation: The Journal of Physiological Sciences 2019 69:697

    Content type: Review

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  43. Serum testosterone concentration decreases with age in humans and rodents. Accordingly, old male mice show changes in locomotor activity rhythms: a lengthened free-running period and decreased activity levels ...

    Authors: Atsuyoshi Hashimoto, Shingo Fujiki, Wataru Nakamura and Takahiro J. Nakamura

    Citation: The Journal of Physiological Sciences 2019 69:695

    Content type: Original Paper

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  44. The effects of the pharyngeal non-noxious mechanical stimulation on the secretion of immunoreactive thyroxin (iT4), immunoreactive calcitonin (iCT), and immunoreactive parathyroid hormone (iPTH) into thyroid v...

    Authors: Kaori Iimura, Harue Suzuki and Harumi Hotta

    Citation: The Journal of Physiological Sciences 2019 69:691

    Content type: Original Paper

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