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  1. Although it has been hypothesized that moderate to vigorous exercise immediately modulates cognition via ascending arousal system activation, such activation during very-light to light exercise has remained un...

    Authors: Ryuta Kuwamizu, Yudai Yamazaki, Naoki Aoike, Genta Ochi, Kazuya Suwabe and Hideaki Soya
    Citation: The Journal of Physiological Sciences 2022 72:23
  2. Pain and itch are recognized as antagonistic sensations; pain suppresses itch and inhibition of pain generates itch. There is still a lack of evidence about the neural mechanism of the interaction between pain...

    Authors: Tatsuroh Kaneko, Tomoyuki Kuwaki and Hideki Kashiwadani
    Citation: The Journal of Physiological Sciences 2022 72:21
  3. Extensive research has found strongly increased generation of reactive oxygen species, free radicals, and reactive nitrogen species during acute physical exercise that can lead to oxidative stress (OS) and imp...

    Authors: Joanna Kruk, Basil Hassan Aboul-Enein, Ewa Duchnik and Mariola Marchlewicz
    Citation: The Journal of Physiological Sciences 2022 72:19
  4. Hypothermia has been observed during hypergravity load in mice and rats. This response is beneficial for maintaining blood glucose level, although food intake decreases. However, saving glucose is not enough t...

    Authors: Chikara Abe, Chikako Katayama, Kazuhiro Horii, Bakushi Ogawa, Kento Ohbayashi, Yusaku Iwasaki, Fumiaki Nin and Hironobu Morita
    Citation: The Journal of Physiological Sciences 2022 72:18
  5. The external globus pallidus (GP) is a GABAergic node involved in motor control regulation and coordinates firing and synchronization in the basal ganglia–thalamic–cortical network through inputs and electrica...

    Authors: Nelson Villalobos, Salvador Almazán-Alvarado and Victor Manuel Magdaleno-Madrigal
    Citation: The Journal of Physiological Sciences 2022 72:17
  6. Emergent evidence suggests that cyclic intermittent hypoxia increases cerebral arterial shear rate and endothelial function, whereas continuous exposure decreases anterior cerebral oxygen (O2) delivery. To examin...

    Authors: Shigehiko Ogoh, Takuro Washio, Benjamin S. Stacey, Hayato Tsukamoto, Angelo Iannetelli, Thomas S. Owens, Thomas A. Calverley, Lewis Fall, Christopher J. Marley and Damian M. Bailey
    Citation: The Journal of Physiological Sciences 2022 72:16
  7. It has been reported that wild-type p53-induced gene 1 (Wig1), which is downstream of p53, regulates the expression of mutant huntingtin protein (mHtt) in Huntington’s disease (HD) patients and transgenic mous...

    Authors: Xin Yang, Heling Zhang, Tong Qu, Yi Wang, Yongxian Zhong, Yuchen Yan, Xuefei Ji, Tiayan Chi, Peng Liu and Libo Zou
    Citation: The Journal of Physiological Sciences 2022 72:15
  8. This study investigated whether endurance training attenuates orchiectomy (ORX)-induced metabolic alterations. At 7 days of recovery after sham operation or ORX surgery, the mice were randomized to remain sede...

    Authors: Kenya Takahashi, Yu Kitaoka and Hideo Hatta
    Citation: The Journal of Physiological Sciences 2022 72:14
  9. Brown adipocytes expend energy via heat production and are a potential target for the prevention of obesity and related metabolic disorders. Piezo1 is a Ca2+-permeable non-selective cation channel activated by me...

    Authors: Manato Kenmochi, Satoko Kawarasaki, Satsuki Takizawa, Kazuhiko Okamura, Tsuyoshi Goto and Kunitoshi Uchida
    Citation: The Journal of Physiological Sciences 2022 72:13
  10. Despite the presence of clinical guidelines recommending that β-blocker treatment be initiated early after reperfused myocardial infarction (RMI), acute myocardial infarction remains a leading cause of chronic...

    Authors: Meihua Li, Can Zheng, Toru Kawada, Kazunori Uemura, Masashi Inagaki, Keita Saku and Masaru Sugimachi
    Citation: The Journal of Physiological Sciences 2022 72:12
  11. Transient receptor potential (TRP) channels are known as temperature receptors. Each channel has an activation temperature in vitro within the physiological temperature range. Mice deficient in specific TRP ch...

    Authors: Tomoyo Ujisawa, Sachiko Sasajima, Makiko Kashio and Makoto Tominaga
    Citation: The Journal of Physiological Sciences 2022 72:11
  12. Hsa_circ_0000345 has been reported to be down-regulated in nasopharyngeal carcinoma (NPC). Whether hsa_circ_0000345 can exert antitumor effect in NPC remains unclear. This study aimed to investigate the possib...

    Authors: Chang Jiang, Hongyan Li, Fei Liu, Linggai Shi, Jun Liu and Yujie Li
    Citation: The Journal of Physiological Sciences 2022 72:10
  13. Neural oscillations synchronize the activity of brain regions during cognitive functions, such as spatial working memory. Olfactory bulb (OB) oscillations are ubiquitous rhythms that can modulate neocortical a...

    Authors: Morteza Salimi, Farhad Tabasi, Milad Nazari, Sepideh Ghazvineh and Mohammad Reza Raoufy
    Citation: The Journal of Physiological Sciences 2022 72:9
  14. We recently reported that subjects with a higher olfactory identification threshold for rose odor declined more in attentional ability in the elderly. This study focuses on discrimination ability and olfactory...

    Authors: Sae Uchida, Chiho Shimada, Naoko Sakuma, Fusako Kagitani, Akiko Kan and Shuichi Awata
    Citation: The Journal of Physiological Sciences 2022 72:8
  15. The physiology of vascular smooth muscle (VSMC) cells is affected by autophagy, a catabolic cellular mechanism responsible for nutrient recycling. Autophagy-inducing compounds may reverse arterial stiffening, ...

    Authors: Dorien G. De Munck, Arthur J. A. Leloup, Sofie De Moudt, Guido R. Y. De Meyer, Wim Martinet and Paul Fransen
    Citation: The Journal of Physiological Sciences 2022 72:7
  16. We investigated the protective effect of losartan, an angiotensin II type 1 receptor blocker, on soleus muscle atrophy. Age-matched male and female Wistar rats were subjected to hindlimb unloading, and the sol...

    Authors: Toshinori Yoshihara, Mizuki Takaragawa, Shohei Dobashi and Hisashi Naito
    Citation: The Journal of Physiological Sciences 2022 72:6
  17. Rodents demonstrate defensive behaviors such as fleeing or freezing upon recognizing a looming shadow above them. Although individuals’ experiences in their habitat can modulate the defensive behavior phenotyp...

    Authors: Madoka Narushima, Masakazu Agetsuma and Junichi Nabekura
    Citation: The Journal of Physiological Sciences 2022 72:5
  18. HCO3 secretion in distal airways is critical for airway mucosal defense. HCO3/H+ transport across the apical membrane of airway surface epithelial cells was studied by measuring intracellular pH in luminally mi...

    Authors: Libin Liu, Akiko Yamamoto, Makoto Yamaguchi, Itsuka Taniguchi, Nao Nomura, Miyuki Nakakuki, Yuka Kozawa, Tomoya Fukuyasu, Mayuko Higuchi, Erina Niwa, Tsutomu Tamada and Hiroshi Ishiguro
    Citation: The Journal of Physiological Sciences 2022 72:4
  19. Osteoarthritis (OA) is a degenerative disease characterized by synovial inflammation. MiR-18a-3p was reported to be downregulated in knee anterior cruciate ligament of OA patients. In the present study, the sp...

    Authors: Xiaoguang Feng, Jiajun Lu, Yixiong Wu and Haiyun Xu
    Citation: The Journal of Physiological Sciences 2022 72:3
  20. We recently reported a positive relationship between occlusal disharmony and cardiovascular disease via activation of β-adrenergic signaling in mice. Furthermore, inhibition of type 5 adenylyl cyclase (AC5), a...

    Authors: Yoshio Hayakawa, Kenji Suita, Yoshiki Ohnuki, Yasumasa Mototani, Misao Ishikawa, Aiko Ito, Megumi Nariyama, Akinaka Morii, Kenichi Kiyomoto, Michinori Tsunoda, Ichiro Matsuo, Hiroshi Kawahara and Satoshi Okumura
    Citation: The Journal of Physiological Sciences 2022 72:2
  21. The entorhinal cortex (EC) plays a pivotal role in epileptogenesis and seizures. EC expresses high density of serotonergic receptors, especially 5-HT3 receptors. Cognitive impairment is common among people with e...

    Authors: Zeynab Sayahi, Alireza Komaki, Masoud Saidi Jam, Seyed Asaad Karimi, Safoura Raoufi, Parastoo Mardani, Marzieh Naderishahab, Abdolrahman Sarihi and Javad Mirnajafi-Zadeh
    Citation: The Journal of Physiological Sciences 2022 72:1
  22. Clonidine is a first-generation central antihypertensive that reduces sympathetic nerve activity (SNA). Although clonidine also exerts peripheral vasoconstriction, the extent to which this vasoconstriction off...

    Authors: Toru Kawada, Takuya Nishikawa, Yohsuke Hayama, Meihua Li, Can Zheng, Kazunori Uemura, Keita Saku, Tadayoshi Miyamoto and Masaru Sugimachi
    Citation: The Journal of Physiological Sciences 2021 71:39
  23. “Inflammaging” refers to the chronic, low-grade inflammation that characterizes aging. Aging, like obesity, is associated with visceral adiposity and insulin resistance. Adipose tissue macrophages (ATMs) have ...

    Authors: Bangchao Lu, Liang Huang, Juan Cao, Lingling Li, Wenhui Wu, Xiaolin Chen and Congzhu Ding
    Citation: The Journal of Physiological Sciences 2021 71:38
  24. Brain malfunction is common in diabetic patients. On the other hand, a growing body of research points to the beneficial effect of medicinal plants and exercise training on insulin sensitivity and brain functi...

    Authors: Hesam Parsa, Zahra Moradi-Khaligh, Sara Rajabi, Kamal Ranjbar and Alireza Komaki
    Citation: The Journal of Physiological Sciences 2021 71:37

    The Correction to this article has been published in The Journal of Physiological Sciences 2022 72:20

  25. The odorant arrives at nasal olfactory epithelium ortho- and retronasally. This experiment aimed to study the potential different olfactory habituation in orthonasal and retronasal pathways. 68 subjects were s...

    Authors: Wei Xiao, Zhifu Sun, Xiaoguang Yan, Xing Gao, Qianwen Lv and Yongxiang Wei
    Citation: The Journal of Physiological Sciences 2021 71:36
  26. It has been suggested that glycogen functions not only in carbohydrate energy storage, but also as molecular sensors capable of activating lipolysis. This study aimed to compare the variation in liver and musc...

    Authors: Kaito Iwayama, Yoko Tanabe, Fumiya Tanji, Takahiro Ohnishi and Hideyuki Takahashi
    Citation: The Journal of Physiological Sciences 2021 71:35
  27. Neuroplasticity is referred to the ability of the nervous system to change its structure or functions as a result of former stimuli. It is a plausible mechanism underlying a dynamic brain through adaptation pr...

    Authors: Masoumeh Kourosh-Arami, Nasrin Hosseini and Alireza Komaki
    Citation: The Journal of Physiological Sciences 2021 71:34
  28. Herein, we aimed to establish an aerobic exercise-induced physiological myocardial hypertrophy zebrafish (Danio rerio) model and to explore the underlying molecular mechanism. After 4 weeks of aerobic exercise, t...

    Authors: Zhanglin Chen, Zuoqiong Zhou, Xiyang Peng, Chenchen Sun, Dong Yang, Chengli Li, Runkang Zhu, Ping Zhang, Lan Zheng and Changfa Tang
    Citation: The Journal of Physiological Sciences 2021 71:33
  29. Our previous study proved that Shen Qi Li Xin formula (SQLXF) improved the heart function of chronic heart failure (CHF) patients, while the action mechanism remains unclear.

    Authors: Yan-Bo Sui, Jian Xiu, Jin-Xuan Wei, Pei-Pei Pan, Bi-Hong Sun and Li Liu
    Citation: The Journal of Physiological Sciences 2021 71:32
  30. In this review, with our current studies we demonstrated medical evidence that water and food intake are useful for IL-22-related mucosal immunity-dependent maintenance of health care. The traditional Japanese...

    Authors: Tomomi Watanabe-Asaka, Moyuru Hayashi, Daisuke Maejima, Yoshiko Kawai and Toshio Ohhashi
    Citation: The Journal of Physiological Sciences 2021 71:31
  31. Endothelial to mesenchymal transition (EndMT) participates in the progression of atherosclerosis (AS). MiR-200c-3p has been implicated in EndMT. However, the functional role of miR-200c-3p in AS remains largel...

    Authors: Yongzhong Mao and Ling Jiang
    Citation: The Journal of Physiological Sciences 2021 71:30
  32. Contingent negative variation (CNV) is an informative electrophysiological measure of pain anticipation showing higher amplitudes when highly painful stimulation is expected while presenting lower amplitudes w...

    Authors: Alessandro Piedimonte, Denisa Adina Zamfira, Giulia Guerra, Sergio Vighetti and Elisa Carlino
    Citation: The Journal of Physiological Sciences 2021 71:29
  33. Sweat is a noninvasive biological fluid on the surface of human skin and has attracted increasing attention as a diagnostic specimen for disease and biomarker detection. Sweat metabolite quantification is poss...

    Authors: Ting-Ting Luo, Zhong-Hai Sun, Chu-Xin Li, Jin-Lian Feng, Zhao-Xiu Xiao and Wei-Dong Li
    Citation: The Journal of Physiological Sciences 2021 71:26
  34. “Salty taste” sensation is evoked when sodium and chloride ions are present together in the oral cavity. The presence of an epithelial cation channel that receives Na+ has previously been reported. However, no mo...

    Authors: Yoichi Kasahara, Masataka Narukawa, Yoshiro Ishimaru, Shinji Kanda, Chie Umatani, Yasunori Takayama, Makoto Tominaga, Yoshitaka Oka, Kaori Kondo, Takashi Kondo, Ayako Takeuchi, Takumi Misaka, Keiko Abe and Tomiko Asakura
    Citation: The Journal of Physiological Sciences 2021 71:23
  35. Adolescence is a critical period in brain development, and it is characterized by persistent maturational alterations in the function of central nervous system. In this respect, many studies show the non-medic...

    Authors: Sara Sabuee, S. Mohammad Ahmadi-Soleimani and Hossein Azizi
    Citation: The Journal of Physiological Sciences 2021 71:25
  36. This study compared the effects of low-intensity resistance exercise with slow movement and tonic force generation (ST-LRE) and high-intensity resistance exercise (HRE) on post-exercise improvements in cogniti...

    Authors: Kento Dora, Tadashi Suga, Keigo Tomoo, Takeshi Sugimoto, Ernest Mok, Hayato Tsukamoto, Shingo Takada, Takeshi Hashimoto and Tadao Isaka
    Citation: The Journal of Physiological Sciences 2021 71:22
  37. Cognitive functions such as working memory require integrated activity among different brain regions. Notably, entorhinal cortex (EC) activity is associated with the successful working memory task. Olfactory b...

    Authors: Morteza Salimi, Farhad Tabasi, Milad Nazari, Sepideh Ghazvineh, Alireza Salimi, Hamidreza Jamaati and Mohammad Reza Raoufy
    Citation: The Journal of Physiological Sciences 2021 71:21
  38. The aim of this study was to examine the mechanisms underlying hypoalgesia induced by spinal manipulation (SM). Eighty-two healthy volunteers were assigned to one of the four intervention groups: no interventi...

    Authors: Benjamin Provencher, Stéphane Northon, Carlos Gevers Montoro, Julie O’Shaughnessy and Mathieu Piché
    Citation: The Journal of Physiological Sciences 2021 71:20
  39. Previous studies have shown that persistent limb immobilization using a cast increases nociceptive behavior to somatic stimuli in rats. However, the peripheral neural mechanisms of nociception remain unclear. ...

    Authors: Hiroki Ota, Haruna Takebe, Kazue Mizumura and Toru Taguchi
    Citation: The Journal of Physiological Sciences 2021 71:19
  40. We examined whether the chemogenetic activation of endogenous arginine vasopressin (AVP) affects central nesfatin-1/NucB2 neurons, using a transgenic rat line that was previously generated. Saline (1 mL/kg) or...

    Authors: Kenya Sanada, Mitsuhiro Yoshimura, Naofumi Ikeda, Kazuhiko Baba, Haruki Nishimura, Kazuaki Nishimura, Yuki Nonaka, Takashi Maruyama, Tetsu Miyamoto, Masatomo Mori, Becky Conway-Campbell, Stafford Lightman, Masaharu Kataoka and Yoichi Ueta
    Citation: The Journal of Physiological Sciences 2021 71:18
  41. We studied the impact of mechanically regulated, expiratory negative airway pressure (ENAP) ventilation on pulmonary and systemic circulation including its mechanisms and potential applications. Microminipigs wei...

    Authors: Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Takeshi Wada, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Keith G. Lurie and Atsushi Sugiyama
    Citation: The Journal of Physiological Sciences 2021 71:17
  42. This study aimed to clarify whether the reflex excitation of muscle sympathetic nerves induced by contractions of the skeletal muscles modulates their contractility. In anesthetized rats, isometric tetanic con...

    Authors: Harumi Hotta, Kaori Iimura, Nobuhiro Watanabe and Kazuhiro Shigemoto
    Citation: The Journal of Physiological Sciences 2021 71:15
  43. High-fat diets (HFDs) and obesity can cause serious health problems, such as neurodegenerative diseases and cognitive impairments. Consumption of HFD is associated with reduction in hippocampal synaptic plasti...

    Authors: Seyed Asaad Karimi, Somayeh Komaki, Masoumeh Taheri, Ghazaleh Omidi, Masoumeh Kourosh-Arami, Iraj Salehi and Alireza Komaki
    Citation: The Journal of Physiological Sciences 2021 71:14
  44. Primary acute sympathetic activation (PASA) causes a subsequent arterial pressure (AP) elevation. In this case, an antidiuretic effect via the renal innervation and pressure diuresis can act antagonistically o...

    Authors: Toru Kawada, Takuya Nishikawa, Satoru Suehara, Satoshi Sawada, Tetsuo Tanaka, Minako Uenohara, Hiromi Yamamoto and Masaru Sugimachi
    Citation: The Journal of Physiological Sciences 2021 71:13

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