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  1. “Inflammaging” refers to the chronic, low-grade inflammation that characterizes aging. Aging, like obesity, is associated with visceral adiposity and insulin resistance. Adipose tissue macrophages (ATMs) have ...

    Authors: Bangchao Lu, Liang Huang, Juan Cao, Lingling Li, Wenhui Wu, Xiaolin Chen and Congzhu Ding

    Citation: The Journal of Physiological Sciences 2021 71:38

    Content type: Mini-review

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  2. Brain malfunction is common in diabetic patients. On the other hand, a growing body of research points to the beneficial effect of medicinal plants and exercise training on insulin sensitivity and brain functi...

    Authors: Hesam Parsa, Zahra Moradi-Khaligh, Sara Rajabi, Kamal Ranjbar and Alireza Komaki

    Citation: The Journal of Physiological Sciences 2021 71:37

    Content type: Original Paper

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  3. The odorant arrives at nasal olfactory epithelium ortho- and retronasally. This experiment aimed to study the potential different olfactory habituation in orthonasal and retronasal pathways. 68 subjects were s...

    Authors: Wei Xiao, Zhifu Sun, Xiaoguang Yan, Xing Gao, Qianwen Lv and Yongxiang Wei

    Citation: The Journal of Physiological Sciences 2021 71:36

    Content type: Original Paper

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  4. It has been suggested that glycogen functions not only in carbohydrate energy storage, but also as molecular sensors capable of activating lipolysis. This study aimed to compare the variation in liver and musc...

    Authors: Kaito Iwayama, Yoko Tanabe, Fumiya Tanji, Takahiro Ohnishi and Hideyuki Takahashi

    Citation: The Journal of Physiological Sciences 2021 71:35

    Content type: Original Paper

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  5. Neuroplasticity is referred to the ability of the nervous system to change its structure or functions as a result of former stimuli. It is a plausible mechanism underlying a dynamic brain through adaptation pr...

    Authors: Masoumeh Kourosh-Arami, Nasrin Hosseini and Alireza Komaki

    Citation: The Journal of Physiological Sciences 2021 71:34

    Content type: Review

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  6. Herein, we aimed to establish an aerobic exercise-induced physiological myocardial hypertrophy zebrafish (Danio rerio) model and to explore the underlying molecular mechanism. After 4 weeks of aerobic exercise, t...

    Authors: Zhanglin Chen, Zuoqiong Zhou, Xiyang Peng, Chenchen Sun, Dong Yang, Chengli Li, Runkang Zhu, Ping Zhang, Lan Zheng and Changfa Tang

    Citation: The Journal of Physiological Sciences 2021 71:33

    Content type: Original Paper

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  7. Our previous study proved that Shen Qi Li Xin formula (SQLXF) improved the heart function of chronic heart failure (CHF) patients, while the action mechanism remains unclear.

    Authors: Yan-Bo Sui, Jian Xiu, Jin-Xuan Wei, Pei-Pei Pan, Bi-Hong Sun and Li Liu

    Citation: The Journal of Physiological Sciences 2021 71:32

    Content type: Original Paper

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  8. In this review, with our current studies we demonstrated medical evidence that water and food intake are useful for IL-22-related mucosal immunity-dependent maintenance of health care. The traditional Japanese...

    Authors: Tomomi Watanabe-Asaka, Moyuru Hayashi, Daisuke Maejima, Yoshiko Kawai and Toshio Ohhashi

    Citation: The Journal of Physiological Sciences 2021 71:31

    Content type: Mini-review

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  9. Endothelial to mesenchymal transition (EndMT) participates in the progression of atherosclerosis (AS). MiR-200c-3p has been implicated in EndMT. However, the functional role of miR-200c-3p in AS remains largel...

    Authors: Yongzhong Mao and Ling Jiang

    Citation: The Journal of Physiological Sciences 2021 71:30

    Content type: Original Paper

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  10. Contingent negative variation (CNV) is an informative electrophysiological measure of pain anticipation showing higher amplitudes when highly painful stimulation is expected while presenting lower amplitudes w...

    Authors: Alessandro Piedimonte, Denisa Adina Zamfira, Giulia Guerra, Sergio Vighetti and Elisa Carlino

    Citation: The Journal of Physiological Sciences 2021 71:29

    Content type: Short Communication

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  11. Sweat is a noninvasive biological fluid on the surface of human skin and has attracted increasing attention as a diagnostic specimen for disease and biomarker detection. Sweat metabolite quantification is poss...

    Authors: Ting-Ting Luo, Zhong-Hai Sun, Chu-Xin Li, Jin-Lian Feng, Zhao-Xiu Xiao and Wei-Dong Li

    Citation: The Journal of Physiological Sciences 2021 71:26

    Content type: Review

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  12. “Salty taste” sensation is evoked when sodium and chloride ions are present together in the oral cavity. The presence of an epithelial cation channel that receives Na+ has previously been reported. However, no mo...

    Authors: Yoichi Kasahara, Masataka Narukawa, Yoshiro Ishimaru, Shinji Kanda, Chie Umatani, Yasunori Takayama, Makoto Tominaga, Yoshitaka Oka, Kaori Kondo, Takashi Kondo, Ayako Takeuchi, Takumi Misaka, Keiko Abe and Tomiko Asakura

    Citation: The Journal of Physiological Sciences 2021 71:23

    Content type: Original Paper

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  13. Adolescence is a critical period in brain development, and it is characterized by persistent maturational alterations in the function of central nervous system. In this respect, many studies show the non-medic...

    Authors: Sara Sabuee, S. Mohammad Ahmadi-Soleimani and Hossein Azizi

    Citation: The Journal of Physiological Sciences 2021 71:25

    Content type: Original Paper

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  14. This study compared the effects of low-intensity resistance exercise with slow movement and tonic force generation (ST-LRE) and high-intensity resistance exercise (HRE) on post-exercise improvements in cogniti...

    Authors: Kento Dora, Tadashi Suga, Keigo Tomoo, Takeshi Sugimoto, Ernest Mok, Hayato Tsukamoto, Shingo Takada, Takeshi Hashimoto and Tadao Isaka

    Citation: The Journal of Physiological Sciences 2021 71:22

    Content type: Original Paper

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  15. Cognitive functions such as working memory require integrated activity among different brain regions. Notably, entorhinal cortex (EC) activity is associated with the successful working memory task. Olfactory b...

    Authors: Morteza Salimi, Farhad Tabasi, Milad Nazari, Sepideh Ghazvineh, Alireza Salimi, Hamidreza Jamaati and Mohammad Reza Raoufy

    Citation: The Journal of Physiological Sciences 2021 71:21

    Content type: Original Paper

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  16. The aim of this study was to examine the mechanisms underlying hypoalgesia induced by spinal manipulation (SM). Eighty-two healthy volunteers were assigned to one of the four intervention groups: no interventi...

    Authors: Benjamin Provencher, Stéphane Northon, Carlos Gevers Montoro, Julie O’Shaughnessy and Mathieu Piché

    Citation: The Journal of Physiological Sciences 2021 71:20

    Content type: Original Paper

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  17. Previous studies have shown that persistent limb immobilization using a cast increases nociceptive behavior to somatic stimuli in rats. However, the peripheral neural mechanisms of nociception remain unclear. ...

    Authors: Hiroki Ota, Haruna Takebe, Kazue Mizumura and Toru Taguchi

    Citation: The Journal of Physiological Sciences 2021 71:19

    Content type: Original Paper

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  18. We examined whether the chemogenetic activation of endogenous arginine vasopressin (AVP) affects central nesfatin-1/NucB2 neurons, using a transgenic rat line that was previously generated. Saline (1 mL/kg) or...

    Authors: Kenya Sanada, Mitsuhiro Yoshimura, Naofumi Ikeda, Kazuhiko Baba, Haruki Nishimura, Kazuaki Nishimura, Yuki Nonaka, Takashi Maruyama, Tetsu Miyamoto, Masatomo Mori, Becky Conway-Campbell, Stafford Lightman, Masaharu Kataoka and Yoichi Ueta

    Citation: The Journal of Physiological Sciences 2021 71:18

    Content type: Original Paper

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  19. We studied the impact of mechanically regulated, expiratory negative airway pressure (ENAP) ventilation on pulmonary and systemic circulation including its mechanisms and potential applications. Microminipigs wei...

    Authors: Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Takeshi Wada, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Keith G. Lurie and Atsushi Sugiyama

    Citation: The Journal of Physiological Sciences 2021 71:17

    Content type: Original Paper

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  20. This study aimed to clarify whether the reflex excitation of muscle sympathetic nerves induced by contractions of the skeletal muscles modulates their contractility. In anesthetized rats, isometric tetanic con...

    Authors: Harumi Hotta, Kaori Iimura, Nobuhiro Watanabe and Kazuhiro Shigemoto

    Citation: The Journal of Physiological Sciences 2021 71:15

    Content type: Original Paper

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  21. High-fat diets (HFDs) and obesity can cause serious health problems, such as neurodegenerative diseases and cognitive impairments. Consumption of HFD is associated with reduction in hippocampal synaptic plasti...

    Authors: Seyed Asaad Karimi, Somayeh Komaki, Masoumeh Taheri, Ghazaleh Omidi, Masoumeh Kourosh-Arami, Iraj Salehi and Alireza Komaki

    Citation: The Journal of Physiological Sciences 2021 71:14

    Content type: Original Paper

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  22. Primary acute sympathetic activation (PASA) causes a subsequent arterial pressure (AP) elevation. In this case, an antidiuretic effect via the renal innervation and pressure diuresis can act antagonistically o...

    Authors: Toru Kawada, Takuya Nishikawa, Satoru Suehara, Satoshi Sawada, Tetsuo Tanaka, Minako Uenohara, Hiromi Yamamoto and Masaru Sugimachi

    Citation: The Journal of Physiological Sciences 2021 71:13

    Content type: Original Paper

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  23. The handgrip exercise, a small muscle exercise, is useful for exercise therapy, particularly in the elderly and bedridden patients. The isometric handgrip (IHG) exercise has been utilized in training programs ...

    Authors: Shotaro Saito, Takuro Washio, Hironori Watanabe, Soichi Ando and Shigehiko Ogoh

    Citation: The Journal of Physiological Sciences 2021 71:12

    Content type: Original Paper

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  24. L-type amino acid transporter 2 (LAT2) is a Na+-independent neutral amino acid transporter, whose function regulation system remains unclarified. Since protein kinase C (PKC) is known to regulate the functions of...

    Authors: Hanae Morio, Yoshie Reien, Yuri Hirayama, Hirofumi Hashimoto and Naohiko Anzai

    Citation: The Journal of Physiological Sciences 2021 71:11

    Content type: Original Paper

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  25. The aim of the present study was to establish a novel method for inducing deep hypothermia in rats. Cooling rats anesthetized with isoflurane caused a time-dependent decrease in rectal temperature, but cardiac...

    Authors: Hiroki Shimaoka, Takahiko Shiina, Hayato Suzuki, Yuuki Horii, Kazuhiro Horii and Yasutake Shimizu

    Citation: The Journal of Physiological Sciences 2021 71:10

    Content type: Original Paper

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  26. Long noncoding RNAs (lncRNAs) play an essential role in the progression of papillary thyroid cancer (PTC). However, the expression and function of lncRNA cancer susceptibility candidate 7 (CASC7) in PTC remain...

    Authors: Wencong Sun and Detao Yin

    Citation: The Journal of Physiological Sciences 2021 71:9

    Content type: Original Paper

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  27. Colonic motor activity is important for the formation and propulsion of feces. The production of prostaglandins (PGs) in colonic tissue is considered to play a critical role in the generation and regulation of...

    Authors: Shin-Ichiro Karaki and Ryo Tanaka

    Citation: The Journal of Physiological Sciences 2021 71:8

    Content type: Original Paper

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  28. Currently available tocolytic agents are not effective treatment for preterm labor beyond 48 h. A major reason is the development of maternal side effects which preclude the maintenance of an effective steady-...

    Authors: Shunsuke Hyuga, Robert C. Parry, Jennifer Danielsson, Joy Vink, Xiao Wen Fu, Amy Wu, William Dan, Peter D. Yim and George Gallos

    Citation: The Journal of Physiological Sciences 2021 71:7

    Content type: Original Paper

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  29. Our previous research has shown that galanin plays an antinociceptive effect via binding to galanin receptors (GalRs) in nucleus accumbens (NAc). This study focused on the involvement of GalR2 in galanin-induc...

    Authors: Yan Dong, Chong-Yang Li, Xiao-Min Zhang, Ya-Nan Liu, Shuang Yang, Meng-Nan Li and Shi-Lian Xu

    Citation: The Journal of Physiological Sciences 2021 71:6

    Content type: Original Paper

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  30. The anion exchanger slc26a3 (DRA), which is mutated in congenital chloride-losing diarrhea, is expressed in the apical membrane of the cecum and middle-distal colon but not in the proximal colon of rodent larg...

    Authors: Hisayoshi Hayashi, Hiroki Nagai, Kou-ichiro Ohba, Manoocher Soleimani and Yuichi Suzuki

    Citation: The Journal of Physiological Sciences 2021 71:5

    Content type: Original Paper

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  31. Discovery of blood biomarkers to evaluate exercise-induced muscle damage have attracted many researchers and coaches. This study aimed to determine changes in circulating myomesin 3 fragments as a novel biomar...

    Authors: Minjung Lee, Jaehoon Shin, Tatsuya Kato, Kazue Kanda, Satoshi Oikawa, Jun Sakuma, Kaoru Sugama, Yasuo Kawakami, Katsuhiko Suzuki and Takayuki Akimoto

    Citation: The Journal of Physiological Sciences 2021 71:4

    Content type: Short Communication

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  32. Ketogenic diets (KD) have become popular diet to lose weight. However, the effect of such diets on brain function has not yet been clarified. Thus, we aimed to study the effects of KD on the neurogenesis and a...

    Authors: Irfannuddin Irfannuddin, Siti Fazzaura Putri Sarahdeaz, Krisna Murti, Budi Santoso and Noriyuki Koibuchi

    Citation: The Journal of Physiological Sciences 2021 71:3

    Content type: Original Paper

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  33. We previously established that the non-neuronal cardiac cholinergic system (NNCCS) is equipped with cardiomyocytes synthesizes acetylcholine (ACh), which is an indispensable endogenous system, sustaining cardi...

    Authors: Shino Oikawa, Yuko Kai, Asuka Mano, Hisayuki Ohata, Atsushi Kurabayashi, Masayuki Tsuda and Yoshihiko Kakinuma

    Citation: The Journal of Physiological Sciences 2021 71:2

    Content type: Original Paper

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  34. We examined the activities of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) and corticotropin-releasing factor (CRF) neurons in the hypothalamic paraventricular nucleus (PVN) during acute treadmil...

    Authors: Ryoko Morikawa, Natsuko Kubota, Seiichiro Amemiya, Takeshi Nishijima and Ichiro Kita

    Citation: The Journal of Physiological Sciences 2021 71:1

    Content type: Original Paper

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  35. Transient ischemia is an exacerbation factor of Alzheimer’s disease (AD). We aimed to examine the influence of amyloid β (Aβ) deposition around the cerebral (pial) artery in terms of diameter changes in the ce...

    Authors: Nobuhiro Watanabe, Yoshihiro Noda, Taeko Nemoto, Kaori Iimura, Takahiko Shimizu and Harumi Hotta

    Citation: The Journal of Physiological Sciences 2020 70:57

    Content type: Short Communication

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  36. The present study aimed to determine the influence of estradiol (E2) and the interaction with circadian phases on thermoregulatory responses to mild heat in female rats. Heat loss and production during 3-h exposu...

    Authors: Shuri Marui, Yuta Masuda, Issei Kato and Kei Nagashima

    Citation: The Journal of Physiological Sciences 2020 70:56

    Content type: Original Paper

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  37. Aging is associated with a progressive loss of skeletal muscle mass and strength, resulting in frailty and lower quality of life in older individuals. At present, a standard of clinical or pharmacological care...

    Authors: Toshinori Yoshihara and Hisashi Naito

    Citation: The Journal of Physiological Sciences 2020 70:55

    Content type: Mini-review

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  38. Insufficient duration of recovery between resistance exercise bouts reduces the effects of exercise training, but the influence on muscle anabolic responses is not fully understood. Here, we investigated the c...

    Authors: Junya Takegaki, Riki Ogasawara, Karina Kouzaki, Satoshi Fujita, Koichi Nakazato and Naokata Ishii

    Citation: The Journal of Physiological Sciences 2020 70:54

    Content type: Original Paper

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  39. We investigated the relationship between impedance parameters and skeletal muscle function in the lower extremities, as well as the effectiveness of impedance parameters in evaluating muscle quality. Lower ext...

    Authors: Hiroki Sato, Takao Nakamura, Toshimasa Kusuhara, Kobara Kenichi, Katsushi Kuniyasu, Takaki Kawashima and Kozo Hanayama

    Citation: The Journal of Physiological Sciences 2020 70:53

    Content type: Original Paper

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  40. Moesin is a member of the ezrin, radixin and moesin (ERM) proteins that are involved in the formation and/or maintenance of cortical actin organization through their cross-linking activity between actin filame...

    Authors: Tomonori Okazaki, Daichi Saito, Masatoshi Inden, Kotoku Kawaguchi, Sayuri Wakimoto, Takashi Nakahari and Shinji Asano

    Citation: The Journal of Physiological Sciences 2020 70:52

    Content type: Original Paper

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  41. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Qingbo Cui, Songbin Fu and Zhaozhu Li

    Citation: The Journal of Physiological Sciences 2020 70:51

    Content type: Correction

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    The original article was published in The Journal of Physiological Sciences 2013 63:s12576-013-0251-1

  42. Pseudomonas aeruginosa (PA) is one of the most common bacteria that causes lung infection in hospital. The aim of our study is to explore the role and action mechanism of NK cells in lung PA infection.

    Authors: Ruiqi Jia, Kuili Cui, Zhenkui Li, Yuan Gao, Bianfang Zhang, Zhixia Wang and Junwei Cui

    Citation: The Journal of Physiological Sciences 2020 70:50

    Content type: Original Paper

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  43. Arginine vasopressin (AVP) neurons play essential roles in sensing the change in systemic osmolarity and regulating AVP release from their neuronal terminals to maintain the plasma osmolarity. AVP exocytosis d...

    Authors: Kaori Sato-Numata, Tomohiro Numata, Yoichi Ueta and Yasunobu Okada

    Citation: The Journal of Physiological Sciences 2020 70:49

    Content type: Original Paper

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  44. This study investigated the relationship between olfaction and cognitive function in 12 elderly people (age: 80.9 ± 1.6) living in the community. Olfactory function was assessed by the identification threshold...

    Authors: Sae Uchida, Chiho Shimada, Naoko Sakuma, Fusako Kagitani, Akiko Kan and Shuichi Awata

    Citation: The Journal of Physiological Sciences 2020 70:48

    Content type: Short Communication

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  45. TRPM7, a member of the melastatin subfamily of transient receptor potential channels, is suggested to be a potential candidate for a physiological Mg2+ channel. However, there is no direct evidence of Mg2+ permea...

    Authors: Michiko Tashiro, Masato Konishi, Ryo Kobayashi, Hana Inoue and Utako Yokoyama

    Citation: The Journal of Physiological Sciences 2020 70:47

    Content type: Short Communication

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  46. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with chronic abdominal pain and altered pain processing. The aim of this study was to examine whether attentional processes c...

    Authors: Nabi Rustamov, Alice Wagenaar-Tison, Elysa Doyer and Mathieu Piché

    Citation: The Journal of Physiological Sciences 2020 70:46

    Content type: Original Paper

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  • Speed
    36 days from submission to first decision
    (reviewed manuscripts)
    29 days from submission to first decision
     (all manuscripts)
    119 days from submission to acceptance
    18 days from acceptance to publication

    Citation Impact
    2.781 - 2-year Impact Factor
    2.836 - 5-year Impact Factor

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