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  1. Experiments measuring evoked potentials require flexible and rapid adjustment of stimulation and recording parameters. In this study, we have developed a recording system and an associated Android application ...

    Authors: Yutaro Oguma, Toshi Nakajima, Megan Elizabeth Young and Ryoi Tamura
    Citation: The Journal of Physiological Sciences 2024 74:30
  2. Growth and differentiation are reduced or stopped during hibernation, an energy conserving strategy in harsh seasons by lowered metabolism and body temperature. However, few studies evaluated this in a same in...

    Authors: Taiga Ishimoto, Hideyuki Kosumi, Ken Natsuga and Yoshifumi Yamaguchi
    Citation: The Journal of Physiological Sciences 2024 74:27
  3. Purines such as ATP are regulatory transmitters in motility of the gastrointestinal tract. The aims of this study were to propose functional roles of purinergic regulation of esophageal motility. An isolated s...

    Authors: Takahiko Shiina, Yuji Suzuki, Kazuhiro Horii, Tomoya Sawamura, Natsufu Yuki, Yuuki Horii and Yasutake Shimizu
    Citation: The Journal of Physiological Sciences 2024 74:26
  4. The purpose of this study was the detection and characterization of synergistic muscle activity. Using T2-map MRI, T2 values for 10 forearm muscles in 11 healthy adult volunteers were obtained in the resting stat...

    Authors: Masayoshi Takamori, Sumikazu Akiyama, Yoshiteru Seo and Takashi Mizushima
    Citation: The Journal of Physiological Sciences 2024 74:25
  5. Actin linked regulatory mechanisms are known to contribute contraction/relaxation in smooth muscle. In order to clarify whether modulation of polymerization/depolymerization of actin filaments affects relaxati...

    Authors: Satoko Mihashi and Masaru Watanabe
    Citation: The Journal of Physiological Sciences 2024 74:24
  6. Cardiac glycosides, known as inhibitors of Na+,K+-ATPase, have anti-cancer effects such as suppression of cancer cell proliferation and induction of cancer cell death. Here, we examined the signaling pathway elic...

    Authors: Mizuki Katoh, Takuto Fujii, Yoshiaki Tabuchi, Takahiro Shimizu and Hideki Sakai
    Citation: The Journal of Physiological Sciences 2024 74:23
  7. Androgen excess and metabolic abnormality largely contribute to the pathogenesis of polycystic ovarian syndrome (PCOS), which primarily precipitates ovarian dysfunction and infertility in reproductive-age wome...

    Authors: Kehinde S. Olaniyi and Stephanie E. Areloegbe
    Citation: The Journal of Physiological Sciences 2024 74:22
  8. Mean circulatory filling pressure, venous return curve, and Guyton’s graphical analysis are basic concepts in cardiovascular physiology. However, some medical students may not know how to view and interpret or...

    Authors: Noritaka Mamorita, Akihiro Takeuchi and Hirotoshi Kamata
    Citation: The Journal of Physiological Sciences 2024 74:21
  9. The purpose of this study was to clarify sex differences in the inhibition of sympathetic vasomotor outflow which is caused by the loading of cardiopulmonary baroreceptors. Ten young males and ten age-matched ...

    Authors: Keisho Katayama, Kana Shiozawa, Jordan B. Lee, Natsuki Seo, Haruna Kondo, Mitsuru Saito, Koji Ishida, Philip J. Millar, Ryoichi Banno and Shigehiko Ogoh
    Citation: The Journal of Physiological Sciences 2024 74:19
  10. Previously, we found that serotonin (5-HT) release in the central nucleus of the amygdala (CeA) of anesthetized rats decreases in response to innocuous stroking of the skin, irrespective of stimulus laterality...

    Authors: Ryota Tokunaga, Hideshi Shibata and Mieko Kurosawa
    Citation: The Journal of Physiological Sciences 2024 74:17
  11. The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here, we investigated the roles of GABAB receptors in network oscilla...

    Authors: Hiroyuki Kanayama, Takashi Tominaga, Yoko Tominaga, Nobuo Kato and Hiroshi Yoshimura
    Citation: The Journal of Physiological Sciences 2024 74:16
  12. Perfluorooctane sulfonate (PFOS) exerts adverse effects on neuronal development in young population. Limited evidences have shown that early-life PFOS exposure holds a potential risk for developing age-related...

    Authors: Ayane Ninomiya, Izuki Amano, Hiraku Suzuki, Yuki Fujiwara, Asahi Haijima and Noriyuki Koibuchi
    Citation: The Journal of Physiological Sciences 2024 74:15
  13. Intraocular pressure (IOP) plays a crucial role in glaucoma development, involving the dynamics of aqueous humor (AH). AH flows in from the ciliary body and exits through the trabecular meshwork (TM). IOP foll...

    Authors: Keisuke Ikegami
    Citation: The Journal of Physiological Sciences 2024 74:14
  14. The TGF-β1/Smad3-signaling pathway and gender differences were investigated in alcoholic liver fibrosis. Mice were divided into female normal, female model, male normal, and male model groups. Liver injury and...

    Authors: Xiaomin Hong, Sanqiang Li, Renli Luo, Mengli Yang, Junfei Wu, Shuning Chen and Siyu Zhu
    Citation: The Journal of Physiological Sciences 2024 74:13
  15. Of the ions involved in myocardial function, Ca2+ is the most important. Ca2+ is crucial to the process that allows myocardium to repeatedly contract and relax in a well-organized fashion; it is the process calle...

    Authors: Satoshi Kurihara and Norio Fukuda
    Citation: The Journal of Physiological Sciences 2024 74:12

    The Correction to this article has been published in The Journal of Physiological Sciences 2024 74:20

  16. Many hormones act on the hypothalamus to control hunger and satiety through various pathways closely associated with several factors. When food is present in the gastro intestinal (GI) tract, enteroendocrine c...

    Authors: Ghinwa M. Barakat, Wiam Ramadan, Ghaith Assi and Noura B. El Khoury
    Citation: The Journal of Physiological Sciences 2024 74:11
  17. Myocardial infarction (MI) frequently leads to cardiac remodeling and failure with impaired life quality, playing an important role in cardiovascular deaths. Although physical exercise is a well-recognized eff...

    Authors: Leisiane G. Dias, Carlos H. O. Reis, Leonardo dos Santos, Walter Krause Neto, Ana Paula Lima-Leopoldo, Julien S. Baker, André S. Leopoldo and Danilo S. Bocalini
    Citation: The Journal of Physiological Sciences 2024 74:10
  18. There are a lot of temperature-sensitive proteins including transient receptor potential (TRP) channels. Some TRP channels are temperature receptors having specific activation temperatures in vitro that are wi...

    Authors: Tomoyo Ujisawa, Jing Lei, Makiko Kashio and Makoto Tominaga
    Citation: The Journal of Physiological Sciences 2024 74:9
  19. The athlete's paradox phenomenon involves the accumulation of intramuscular triglycerides (IMTG) in both insulin-resistant and insulin-sensitive endurance athletes. Nevertheless, a complete understanding of th...

    Authors: Lin Li, Xiangdeng Lai, Yihan Ni, Siyu Chen, Yaqian Qu, Zhiqiang Hu and Jingquan Sun
    Citation: The Journal of Physiological Sciences 2024 74:8
  20. Folic acid (FA), with its anti-inflammatory and antioxidant properties, may offer protection against ischemia–reperfusion (IR) injury. This study investigated whether FA safeguards rat kidneys from IR by targe...

    Authors: Aya E. H. Hamed, Sherif Khedr, Elsayed Ghonamy, Faten A. Mahmoud and Mona A. Ahmed
    Citation: The Journal of Physiological Sciences 2024 74:7
  21. The digitization of aircraft cockpits places high demands on the colour vision of pilots. The present study investigates colour vision changes upon acute exposure to hypobaric hypoxia. The digital Waggoner Com...

    Authors: F. Liebold, W. Adler, S. Jansen, J. P. Klussmann, M. Meyer, L. Nehrlich, J. Schmitz, A. Vingerhoets, L. M. Heindl and J. Hinkelbein
    Citation: The Journal of Physiological Sciences 2024 74:6
  22. Sepsis-induced acute lung injury (ALI) accounts for about 40% of ALI, accompanied by alveolar epithelial injury. The study aimed to reveal the role of circular RNA_0114428 (circ_0114428) in sepsis-induced ALI.

    Authors: Jing Zhao, Qin Zhao and Qiuxia Duan
    Citation: The Journal of Physiological Sciences 2024 74:5
  23. The volume-sensitive outwardly rectifying or volume-regulated anion channel, VSOR/VRAC, which was discovered in 1988, is expressed in most vertebrate cell types and is essentially involved in cell volume regul...

    Authors: Yasunobu Okada
    Citation: The Journal of Physiological Sciences 2024 74:3
  24. Establishing specific reference intervals (RIs) of serum 25-hydroxyvitamin D3 [25(OH)D] for children is essential for improving the accuracy of diagnosis and prognosis monitoring of diseases such as rickets an...

    Authors: Dong-yi Zhou, Shang-mou Wei, Chun-ling Zhu, Yu-hong Wei, Xiao-mei Wang, Li-ling Yi, Si-tao Yang and Qi-liu Peng
    Citation: The Journal of Physiological Sciences 2024 74:2
  25. In humans, uric acid is an end-product of purine metabolism. Urate excretion from the human kidney is tightly regulated by reabsorption and secretion. At least eleven genes have been identified as human renal ...

    Authors: Yoshihiko M. Sakaguchi, Pattama Wiriyasermkul, Masaya Matsubayashi, Masaki Miyasaka, Nau Sakaguchi, Yoshiki Sahara, Minoru Takasato, Kaoru Kinugawa, Kazuma Sugie, Masahiro Eriguchi, Kazuhiko Tsuruya, Hiroki Kuniyasu, Shushi Nagamori and Eiichiro Mori
    Citation: The Journal of Physiological Sciences 2024 74:1
  26. Mice fed a single meal daily at a fixed time display food anticipatory activity (FAA). It has been reported that the insular cortex (IC) plays an essential role in food anticipation, and lateral hypothalamus (...

    Authors: Jihao Ma, Sakurako Yanase, Lisa Udagawa, Tomoyuki Kuwaki and Ikue Kusumoto-Yoshida
    Citation: The Journal of Physiological Sciences 2023 73:34
  27. Plasticity is a common feature of synapses that is stated in different ways and occurs through several mechanisms. The regular action of the brain needs to be balanced in several neuronal and synaptic features...

    Authors: Masoumeh Kourosh-Arami, Alireza Komaki, Masoumeh Gholami, Seyed Hossein Marashi and Sara Hejazi
    Citation: The Journal of Physiological Sciences 2023 73:33
  28. This study was designed to probe the effect of chaperone-assisted selective autophagy (CASA) on the maintenance of proteostasis during exhaustive exercise and uncover the alteration of CASA in muscle fibers wi...

    Authors: Jiao Lu, Liu-mei Zhang, Jing-jing Liu, Yu-ting Liu, Xiao-ye Lin, Xue-qi Wang, Yuan Zhang, Qiang Tang and Lin Liu
    Citation: The Journal of Physiological Sciences 2023 73:32
  29. Complications such as diabetes and preeclampsia can occur during pregnancy. Moderate-intensity exercise can prevent such complications by releasing placentokines and exerkines, such as apelin, adiponectin, lep...

    Authors: Hamed Alizadeh Pahlavani, Ismail Laher, Katja Weiss, Beat Knechtle and Hassane Zouhal
    Citation: The Journal of Physiological Sciences 2023 73:30
  30. Thrombospondin-1 (TSP1) contributes to obesity-associated inflammation via activating Toll-like receptor 4 (TLR4). The regulatory role of vitamin D on this pathway has been suggested. This study aimed to inves...

    Authors: Eman Y. Khairy and Azza Saad
    Citation: The Journal of Physiological Sciences 2023 73:29
  31. Duchenne muscular dystrophy (DMD) is an inherited disorder with mutations in the dystrophin gene characterized by progressive muscle degeneration and weakness. Therapy such as administration of glucocorticoids...

    Authors: Sawako Yoshina, Luna Izuhara, Rei Mashima, Yuka Maejima, Naoyuki Kamatani and Shohei Mitani
    Citation: The Journal of Physiological Sciences 2023 73:28
  32. Emery–Dreifuss muscular dystrophy (EDMD), caused by mutations in genes encoding nuclear envelope proteins, is clinically characterized by muscular dystrophy, early joint contracture, and life-threatening cardi...

    Authors: Eiji Wada, Kohei Matsumoto, Nao Susumu, Megumi Kato and Yukiko K. Hayashi
    Citation: The Journal of Physiological Sciences 2023 73:27
  33. Heat acclimation/acclimatisation (HA) mitigates heat-related decrements in physical capacity and heat-illness risk and is a widely advocated countermeasure for individuals operating in hot environments. The ef...

    Authors: J. Corbett, J. S. Young, M. J. Tipton, J. T. Costello, T. B. Williams, E. F. Walker, B. J. Lee and C. E. Stevens
    Citation: The Journal of Physiological Sciences 2023 73:26
  34. The regional differences in cerebral oxygen extraction fraction (OEF) in brain were investigated using positron emission tomography (PET) in detail with consideration of systemic errors in PET measurement esti...

    Authors: Hiroshi Ito, Masanobu Ibaraki, Ryo Yamakuni, Motoharu Hakozaki, Naoyuki Ukon, Shiro Ishii, Kenji Fukushima, Hitoshi Kubo and Kazuhiro Takahashi
    Citation: The Journal of Physiological Sciences 2023 73:25
  35. Mast cells are present in mucosal and connective tissues throughout the body. They synthesize and release a wide variety of bioactive molecules, such as histamine, proteases, and cytokines. In this study, we f...

    Authors: Yusuke Otani, Soichiro Yoshikawa, Kei Nagao, Takehiro Tanaka, Shinichi Toyooka and Atsushi Fujimura
    Citation: The Journal of Physiological Sciences 2023 73:24
  36. A metabolite of acetaminophen, AM404, which is an anandamide transporter inhibitor, induces analgesia mainly via activation of transient receptor potential channel 1 in the spinal cord, although the role of ca...

    Authors: Kayo Tsuzawa, Hiroshi Onimaru, Katsunori Inagaki and Masahiko Izumizaki
    Citation: The Journal of Physiological Sciences 2023 73:23
  37. CCN5/WISP2 is prominently manifest in adipose tissue and has been linked to the pathogenesis of obesity, diabetes, and insulin resistance. However, discrepancies exist in previous studies, and little is known ...

    Authors: Mohammed Farhan Hamdan Alshganbee, Fariba Nabatchian, Vida Farrokhi, Reza Fadaei, Nariman Moradi and Reza Afrisham
    Citation: The Journal of Physiological Sciences 2023 73:22
  38. Intracellular calcium (Ca2+) signaling regulates many cellular functions, including cell proliferation and migration, in both normal cells and cancer cells. Store-operated Ca2+ entry (SOCE) is a major mechanism b...

    Authors: Masanari Umemura, Rina Nakakaji and Yoshihiro Ishikawa
    Citation: The Journal of Physiological Sciences 2023 73:21
  39. Sodium–glucose cotransporter 2 (SGLT2) inhibitors have exerted cardioprotective effects in clinical trials, but underlying mechanisms are not fully understood. As mitigating sympathetic overactivity is of majo...

    Authors: Toru Kawada, Meihua Li, Akitsugu Nishiura, Yuki Yoshida, Shohei Yokota, Hiroki Matsushita, Masafumi Fukumitsu, Kazunori Uemura, Joe Alexander Jr and Keita Saku
    Citation: The Journal of Physiological Sciences 2023 73:20
  40. Neural stem cells (NSCs) are maintained in the adult mammalian brain throughout the animal’s lifespan. NSCs in the subependymal zone infrequently divide and generate transit amplifying cells, which are destine...

    Authors: Zakiyyah Munirah Mohd Zaki, Anri Kuroda, Naoko Morimura, Yoshitaka Hayashi and Seiji Hitoshi
    Citation: The Journal of Physiological Sciences 2023 73:19
  41. In this work, we examined the involvement of type 5 adenylyl cyclase (AC5) in cardiac dysfunction induced in mice given Porphyromonas gingivalis lipopolysaccharide (PG-LPS) at a dose equivalent to the circulating...

    Authors: Michinori Tsunoda, Ichiro Matsuo, Yoshiki Ohnuki, Kenji Suita, Misao Ishikawa, Takao Mitsubayashi, Aiko Ito, Yasumasa Mototani, Kenichi Kiyomoto, Akinaka Morii, Megumi Nariyama, Yoshio Hayakawa, Kazuhiro Gomi and Satoshi Okumura
    Citation: The Journal of Physiological Sciences 2023 73:18
  42. Dyslipidemia is an imbalance of various lipids, and propolis, as a natural resinous viscos mixture made by Apis mellifera L. could improve in this condition. In this single-blind, randomized trial, 60 women with ...

    Authors: Fatemeh Moayedi, Farzaneh Taghian, Khosro Jalali Dehkordi and Seyed Ali Hosseini
    Citation: The Journal of Physiological Sciences 2023 73:17
  43. Cephalic-phase insulin release (CPIR) occurs before blood glucose increases after a meal. Although glucose is the most plausible cue to induce CPIR, peripheral sensory systems involved are not fully elucidated...

    Authors: Mitsuhito Takamori, Yoshihiro Mitoh, Kengo Horie, Masahiko Egusa, Takuya Miyawaki and Ryusuke Yoshida
    Citation: The Journal of Physiological Sciences 2023 73:16

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