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  1. Acute loss of kidney function is a critical internal stressor. Arginine vasopressin (AVP) present in the parvocellular division of the paraventricular nucleus (PVN) plays a key role in the regulation of stress...

    Authors: Hiromichi Ueno, Ryota Serino, Kenya Sanada, Yasuki Akiyama, Kentaro Tanaka, Haruki Nishimura, Kazuaki Nishimura, Satomi Sonoda, Yasuhito Motojima, Reiko Saito, Mitsuhiro Yoshimura, Takashi Maruyama, Tetsu Miyamoto, Masahito Tamura, Yutaka Otsuji and Yoichi Ueta

    Citation: The Journal of Physiological Sciences 2019 69:675

    Content type: Original Paper

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  2. Post-myocardial infarction (MI) exercise has been employed to improve cardiac function. However, most studies have focused on endurance training (Et). Although Et has been reported to preserve cardiac function...

    Authors: Michael A. Garza, Emily A. Wason, Justin R. Cruger, Eunhee Chung and John Q. Zhang

    Citation: The Journal of Physiological Sciences 2019 69:672

    Content type: Original Paper

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  3. Voltage-gated potassium channels are expressed in a wide variety of excitable and non-excitable cells and regulate numerous cellular functions. The activity of ion channels can be modulated by direct interacti...

    Authors: Mayra Delgado-Ramírez and Aldo A. Rodríguez-Menchaca

    Citation: The Journal of Physiological Sciences 2019 69:671

    Content type: Original Paper

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  4. An organism stems from assemblies of a variety of cells and proteins. This complex system serves as a unit, and it exhibits highly sophisticated functions in response to exogenous stimuli that change over time...

    Authors: Shinichi Uchida, Yoshiyuki Asai, Yoshiaki Kariya, Kunichika Tsumoto, Hiroshi Hibino, Masashi Honma, Takeshi Abe, Fumiaki Nin, Yasutaka Kurata, Kazuharu Furutani, Hiroshi Suzuki, Hiroaki Kitano, Ryuji Inoue and Yoshihisa Kurachi

    Citation: The Journal of Physiological Sciences 2019 69:667

    Content type: Review

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  5. An uncontrolled inflammatory response has been implicated in the progression of acute liver failure through poorly understood mechanisms. The aim of our study was to investigate whether suramin attenuates infl...

    Authors: Aizhong Wang, Jiali Wang, Jun Wu, Xiaojun Deng and Yan Zou

    Citation: The Journal of Physiological Sciences 2019 69:666

    Content type: Original Paper

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  6. Xanthoceraside, a novel triterpenoid saponin, has been found to attenuate learning and memory impairments in AD animal models. However, whether xanthoceraside has a positive effect on synaptic morphology remai...

    Authors: Ge Jin, Lin Zhu, Peng Liu, Qian Xu, Yue Qi, Xiaoyu Zhou, Jikai Xu, Xuefei Ji, Tianyan Chi and Libo Zou

    Citation: The Journal of Physiological Sciences 2019 69:664

    Content type: Original Paper

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  7. The neuronal K+–Cl cotransporter KCC2 maintains a low intracellular Cl concentration and facilitates hyperpolarizing GABAA receptor responses. KCC2 also plays a separate role in stabilizing and enhancing dendri...

    Authors: Kayo Nakamura, Andrew John Moorhouse, Dennis Lawrence Cheung, Kei Eto, Ikuko Takeda, Paul Wiers Rozenbroek and Junichi Nabekura

    Citation: The Journal of Physiological Sciences 2019 69:654

    Content type: Original Paper

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  8. Pyridoxine (vitamin B6) toxicity is a well-known model for peripheral neuropathy. GABA and glutamate are two neurotransmitters in neural pathways involved in the peripheral neuropathy. Cichorium intybus (Chicory)...

    Authors: Farkhonde Hasannejad, Malek Moein Ansar, Mohammad Rostampour, Edris Mahdavi Fikijivar and Behrooz Khakpour Taleghani

    Citation: The Journal of Physiological Sciences 2019 69:659

    Content type: Original Paper

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  9. Methamphetamine (METH) is a psychostimulant. The precise mechanisms of its effects remain unknown and current relapse treatments have low efficacy. However, brain-derived neurotrophic factor (BDNF) and neurona...

    Authors: Siamak Shahidi, Alireza Komaki, Reihaneh Sadeghian and Sara Soleimani Asl

    Citation: The Journal of Physiological Sciences 2019 69:660

    Content type: Original Paper

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  10. Mediodorsal thalamic nucleus (MD) is a critical relay of nociception. This study recorded responses of MD neurons to noxious mechanical and thermal stimuli in isoflurane anesthetized rats. We found the thresho...

    Authors: Pen-Li Lu, Meng-Li Tsai, Fu-Shan Jaw and Chen-Tung Yen

    Citation: The Journal of Physiological Sciences 2019 69:656

    Content type: Original Paper

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  11. Sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) mediate the high- and low-affinity transport of lactate in the kidney, but their regulatory mechanism is still unknown. Since these t...

    Authors: Sunena Srivastava, Kiyoshi Nakagawa, Xin He, Toru Kimura, Toshiyuki Fukutomi, Seiji Miyauchi, Hiroyuki Sakurai and Naohiko Anzai

    Citation: The Journal of Physiological Sciences 2019 69:658

    Content type: Original Paper

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  12. The present study examined the effect of muscle metaboreflex on blood flow in different cerebral arteries. Eleven healthy participants performed isometric, one-leg knee extension at 30% maximal voluntary contr...

    Authors: Shigehiko Ogoh, Kohei Sato, Ai Hirasawa and Tomoko Sadamoto

    Citation: The Journal of Physiological Sciences 2019 69:653

    Content type: Original Paper

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  13. The present study examined the effects of nicotinic acetylcholine receptor activation on the odor-induced blood flow response in the olfactory bulb. In urethane-anesthetized rats, odor stimulation (5% amyl ace...

    Authors: Sae Uchida, Yoshie Ito and Fusako Kagitani

    Citation: The Journal of Physiological Sciences 2019 69:657

    Content type: Short Communication

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  14. T-type channels are low-voltage-activated channels that play a role in the cardiovascular system particularly for pacemaker activity. Glycosylation is one of the most prevalent post-translational modifications...

    Authors: Yangong Liu, Pu Wang, Fangfang Ma, Mingqi Zheng, Gang Liu, Shinichiro Kume, Tatsuki Kurokawa and Katsushige Ono

    Citation: The Journal of Physiological Sciences 2019 69:650

    Content type: Original Paper

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  15. Mitochondrial iron is indispensable for heme biosynthesis and iron–sulfur cluster assembly. Several mitochondrial transmembrane proteins have been implicated to function in the biosynthesis of heme and iron–su...

    Authors: Ei Ei Mon, Fan-Yan Wei, Raja Norazireen Raja Ahmad, Takahiro Yamamoto, Toshiro Moroishi and Kazuhito Tomizawa

    Citation: The Journal of Physiological Sciences 2018 69:652

    Content type: Original Paper

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  16. The slow force response (SFR) to stretch is an important adaptive mechanism of the heart. The SFR may result in ~ 20–30% extra force but it is substantially attenuated in heart failure. We investigated the rel...

    Authors: Oleg Lookin and Yuri Protsenko

    Citation: The Journal of Physiological Sciences 2018 69:651

    Content type: Original Paper

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  17. Statins and exercise reduce cardiovascular disease incidence. We investigated whether endurance exercise in mice induces mitochondrial adaptation in skeletal muscle and muscle injury during administration of a...

    Authors: Koji Nonaka, Yutaka Ozaki, Kenichi Ito, Masahiro Sakita, Satsuki Une and Junichi Akiyama

    Citation: The Journal of Physiological Sciences 2018 69:649

    Content type: Original Paper

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  18. The purpose of the present study was to determine the effects of transcutaneous CO2 application on the blood flow and capillary architecture of the soleus muscle in rats with streptozotocin (STZ)-induced hypergly...

    Authors: Tomohiro Matsumoto, Masayuki Tanaka, Takuya Ikeji, Noriaki Maeshige, Yoshitada Sakai, Toshihiro Akisue, Hiroyo Kondo, Akihiko Ishihara and Hidemi Fujino

    Citation: The Journal of Physiological Sciences 2018 69:648

    Content type: Original Paper

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  19. FK506 (tacrolimus) is an immunosuppressant widely used as an ointment in the treatment of atopic dermatitis. However, local application of FK506 can evoke burning sensations in atopic dermatitis patients, and ...

    Authors: Tomo Kita, Kunitoshi Uchida, Kenichi Kato, Yoshiro Suzuki, Makoto Tominaga and Jun Yamazaki

    Citation: The Journal of Physiological Sciences 2018 69:647

    Content type: Original Paper

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  20. Vagal nerve stimulation (VNS) induces bradycardia in chronic heart failure (CHF). We hypothesized that beta-blocker would cover the beneficial effects of VNS on CHF if the anti-beta-adrenergic effect was the m...

    Authors: Meihua Li, Can Zheng, Toru Kawada, Masashi Inagaki, Kazunori Uemura and Masaru Sugimachi

    Citation: The Journal of Physiological Sciences 2018 69:646

    Content type: Original Paper

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  21. Acute opioid withdrawal syndrome is a series of neurological symptoms caused by the abrupt cessation of the chronic administration of opioids such as morphine. The locus coeruleus (LC) in the brain stem receiv...

    Authors: Mahnaz Davoudi, Hossein Azizi, Javad Mirnajafi-Zadeh and Saeed Semnanian

    Citation: The Journal of Physiological Sciences 2018 69:645

    Content type: Original Paper

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  22. Pinocytosis is an important fundamental cellular process that is used by the cell to transport fluid and solutes. Phosphoinositide 3-kinases (PI3Ks) regulate a diverse array of dynamic membrane events. However...

    Authors: Khin Thuzar Aung, Kazuaki Yoshioka, Sho Aki, Kazuhiro Ishimaru, Noriko Takuwa and Yoh Takuwa

    Citation: The Journal of Physiological Sciences 2018 69:644

    Content type: Original Paper

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  23. Ia excitation and recurrent inhibition are basic neuronal circuits in motor control in hind limb. Renshaw cells receive synaptic inputs from axon collaterals of motoneurons and inhibit motoneurons and Ia inhib...

    Authors: Masatoshi Niwa, Ken Muramatsu, Kiyomi Nakayama and Sei-Ichi Sasaki

    Citation: The Journal of Physiological Sciences 2018 69:643

    Content type: Original Paper

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  24. This study aimed to investigate the effects of various types of exercise on organic anion transporter 3 (Oat3) function, a major transporter that plays a role in the secretion of a variety of drugs and endogen...

    Authors: Tipwadee Bunprajun, Chaowalit Yuajit, Rattikarn Noitem and Varanuj Chatsudthipong

    Citation: The Journal of Physiological Sciences 2018 69:641

    Content type: Original Paper

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  25. We tested the hypothesis that there are sex differences in hindlimb unloading-induced activation of the forkhead box subfamily O3a (FoxO3a) signaling pathway in rat soleus muscle. Age-matched male and female W...

    Authors: Toshinori Yoshihara, Toshiharu Natsume, Takamasa Tsuzuki, Shuo-wen Chang, Ryo Kakigi, Takao Sugiura and Hisashi Naito

    Citation: The Journal of Physiological Sciences 2018 69:640

    Content type: Original Paper

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  26. The protective effects of Brazilian propolis on capillary regression induced by chronically neuromuscular inactivity were investigated in rat soleus muscle. Four groups of male Wistar rat were used in this stu...

    Authors: Masayuki Tanaka, Miho Kanazashi, Noriaki Maeshige, Hiroyo Kondo, Akihiko Ishihara and Hidemi Fujino

    Citation: The Journal of Physiological Sciences 2018 69:639

    Content type: Original Paper

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  27. We aimed to determine whether acupuncture to the auricular region increases cortical regional cerebral blood flow (rCBF). The rCBF was measured using laser speckle contrast imaging in urethane-anesthetized rat...

    Authors: Sae Uchida, Hiroshi Taniguchi, Yoshie Ito and Fusako Kagitani

    Citation: The Journal of Physiological Sciences 2018 69:637

    Content type: Short Communication

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  28. Ivabradine is a selective bradycardic agent that inhibits hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. HCN channels play a key role in mediating the positive chronotropic response to sym...

    Authors: Toru Kawada, Shuji Shimizu, Kazunori Uemura, Yohsuke Hayama, Hiromi Yamamoto, Toshiaki Shishido, Takuya Nishikawa and Masaru Sugimachi

    Citation: The Journal of Physiological Sciences 2018 69:636

    Content type: Original Paper

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  29. Bradykinin (BK) and its receptors, B1 and B2, in trigeminal ganglion (TG) neurons are involved in the regulation of pain. Recent studies have revealed that B1 receptors are expressed in neonatal rat TG neurons; h...

    Authors: Reiko Terashima, Maki Kimura, Asuka Higashikawa, Yuki Kojima, Tatsuya Ichinohe, Masakazu Tazaki and Yoshiyuki Shibukawa

    Citation: The Journal of Physiological Sciences 2018 69:635

    Content type: Original Paper

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  30. Mitochondrial homeostasis is closely associated with liver cancer progression via multiple mechanisms and is also a potential tumour-suppressive target in clinical practice. However, the role of mitochondrial ...

    Authors: Jian Cao, Runjie Wei and Shukun Yao

    Citation: The Journal of Physiological Sciences 2018 69:634

    Content type: Original Paper

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  31. In the original publication of the article, there are following misprints in the numbering of the planned symposia

    Authors:

    Citation: The Journal of Physiological Sciences 2018 69:633

    Content type: Correction

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    The original article was published in The Journal of Physiological Sciences 2018 68:s12576-018-0610-z

  32. Vascular smooth muscle cell (VSMC) migration and the subsequent intimal thickening play roles in vascular restenosis. We previously reported that an exchange protein activated by cAMP 1 (Epac1) promotes platel...

    Authors: Yuko Kato, Utako Yokoyama, Takayuki Fujita, Masanari Umemura, Tetsuo Kubota and Yoshihiro Ishikawa

    Citation: The Journal of Physiological Sciences 2018 69:631

    Content type: Original Paper

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  33. Although multiple factors influence food bite size, the relationship between food bite size per mouthful and mandible or tongue size remains poorly understood. Here, we examined the correlations between food b...

    Authors: Kouichi Shiozawa, Yasumasa Mototani, Kenji Suita, Aiko Ito, Naoya Kawamura, Yuka Yagisawa, Ichiro Matsuo, Yoshio Hayakawa, Megumi Nariyama, Daisuke Umeki, Yasutake Saeki, Yoshiki Ohnuki and Satoshi Okumura

    Citation: The Journal of Physiological Sciences 2018 69:630

    Content type: Short Communication

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  34. Japanese women can experience a sensation of cold feet in daily life. It is possible that this sensation of coldness in feet may be associated with female hormones, but to date the effect of menstrual cycle ph...

    Authors: Yuki Uchida, Koyuki Atsumi, Akira Takamata and Keiko Morimoto

    Citation: The Journal of Physiological Sciences 2018 69:629

    Content type: Short Communication

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  35. The mechanism of proton pump inhibitors (PPIs) suppressing intestinal Mg2+ uptake is unknown. The present study aimed to investigate the role of purinergic P2Y receptors in the regulation of Mg2+ absorption in no...

    Authors: Narongrit Thongon and Siriporn Chamniansawat

    Citation: The Journal of Physiological Sciences 2018 69:628

    Content type: Original Paper

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  36. Cardiac ischemia–reperfusion (I/R) injury results mainly from mitochondrial dysfunction and cardiomyocyte death. Mitophagy sustains mitochondrial function and exerts a pro-survival effect on the reperfused hea...

    Authors: Wancheng Yu, Mei Xu, Tao Zhang, Qian Zhang and Chengwei Zou

    Citation: The Journal of Physiological Sciences 2018 69:627

    Content type: Original Paper

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  37. To examine whether TRPM7, a member of the melastatin family of transient receptor potential channels, is a physiological pathway for Mg2+ entry in mammalian cells, we studied the effect of TRPM7 regulators on cyt...

    Authors: Michiko Tashiro, Hana Inoue and Masato Konishi

    Citation: The Journal of Physiological Sciences 2018 69:625

    Content type: Original Paper

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  38. Little is known about the effects of glucagon-like peptide 1 (GLP-1) on the pancreatic exocrine gland. In the gland, secretagogues induce amylase release. That signal transduction is evoked mainly by an increa...

    Authors: Keitaro Satoh, Motoshi Ouchi, Asuka Morita and Masanori Kashimata

    Citation: The Journal of Physiological Sciences 2018 69:621

    Content type: Short Communication

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  39. Our aim was to verify whether running a marathon is associated with changes in irisin concentration in healthy, endurance-trained men. In an observational study, we assessed baseline biochemical and fitness pa...

    Authors: Paweł Jóźków, Dawid Koźlenia, Katarzyna Zawadzka, Marek Konefał, Paweł Chmura, Katarzyna Młynarska, Michał Kosowski, Marek Mędraś, Jan Chmura, Piotr Ponikowski and Jacek Daroszewski

    Citation: The Journal of Physiological Sciences 2018 69:619

    Content type: Original Paper

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  40. To investigate how the functional architecture is organized in layer 5 (L5) of the somatosensory cortex of a mouse in vivo, the input–output relationship was investigated using an all-optical approach. The neu...

    Authors: Kyo Koizumi, Masatoshi Inoue, Srikanta Chowdhury, Haruhiko Bito, Akihiro Yamanaka, Toru Ishizuka and Hiromu Yawo

    Citation: The Journal of Physiological Sciences 2018 69:618

    Content type: Original Paper

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  41. Diabetes mellitus is associated with the development of neuronal tissue damage in different central and peripheral nervous system regions. A common complication of diabetes is painful diabetic peripheral neuro...

    Authors: Bahram Rasoulian, Zahra Hajializadeh, Saeed Esmaeili-Mahani, Marzieh Rashidipour, Iman Fatemi and Ayat Kaeidi

    Citation: The Journal of Physiological Sciences 2018 69:620

    Content type: Original Paper

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  42. The membrane trafficking events that regulate unicellular tube formation and maintenance are not well understood. Here, using an RNAi screen, we identified the small GTPase ARF1 homolog ARF-1.2 as a regulator ...

    Authors: Eriko Kage-Nakadai, Simo Sun, Satoru Iwata, Sawako Yoshina, Yoshikazu Nishikawa and Shohei Mitani

    Citation: The Journal of Physiological Sciences 2018 69:617

    Content type: Original Paper

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  43. We examined the effect of intake of a catechin-enriched ion beverage (Cat-I) on the thermoregulatory response in a hot environment. Eight healthy men were exposed to a hot environment for 90 min at an ambient ...

    Authors: Rumiko Nishimura, Naoki Nishimura, Satoshi Iwase, Masao Takeshita, Mitsuhiro Katashima, Yoshihisa Katsuragi and Motohiko Sato

    Citation: The Journal of Physiological Sciences 2018 69:615

    Content type: Original Paper

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  44. This study aimed to investigate the effect of downhill walking on muscle damage and glucose metabolism in healthy subjects. All ten healthy young men and women (age, 24.0 ± 1.4 years) performed rest, uphill wa...

    Authors: Airi Nakayama, Wataru Aoi, Maki Takami, Nariyuki Hirano, Yumi Ogaya, Sayori Wada and Akane Higashi

    Citation: The Journal of Physiological Sciences 2018 69:614

    Content type: Original Paper

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  45. In Syrian hamsters, brown adipose tissue (BAT) develops postnatally through the proliferation and differentiation of brown adipocyte progenitors. In the study reported here, we investigated how ambient tempera...

    Authors: Kazuki Nagaya, Yuko Okamatsu-Ogura, Junko Nio-Kobayashi, Shohei Nakagiri, Ayumi Tsubota and Kazuhiro Kimura

    Citation: The Journal of Physiological Sciences 2018 69:606

    Content type: Original Paper

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  46. Neurological examination remains the primary clinical investigation in patients with spinal cord injury. However, neuroimaging methods such as functional magnetic resonance imaging (fMRI) are promising tools f...

    Authors: Thierry Paquette, Hugues Leblond and Mathieu Piché

    Citation: The Journal of Physiological Sciences 2018 69:607

    Content type: Original Paper

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    (reviewed manuscripts)
    29 days from submission to first decision
     (all manuscripts)
    119 days from submission to acceptance
    18 days from acceptance to publication

    Citation Impact
    2.781 - 2-year Impact Factor
    2.836 - 5-year Impact Factor

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