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  1. Pulmonary vein (PV) cardiomyocytes have the potential to generate spontaneous activity, in contrast to working myocytes of atria. Different electrophysiological properties underlie the potential automaticity o...

    Authors: Daichi Takagi, Yosuke Okamoto, Takayoshi Ohba, Hiroshi Yamamoto and Kyoichi Ono
    Citation: The Journal of Physiological Sciences 2020 70:6
  2. While our recent studies have suggested that effective acupoints display neurogenic inflammation and can be identified as neurogenic spots (Neuro-Sps), the optimal stimulation conditions and the underlying mec...

    Authors: Joo Hyun Shin, Yu Fan, Do-Hee Kim, Han Byeol Jang, Suchan Chang, Yeonhee Ryu, Jong Han Bae, Sanghag Lee, Bong Hyo Lee, Scott C. Steffensen, Chae Ha Yang and Hee Young Kim
    Citation: The Journal of Physiological Sciences 2020 70:14
  3. We have previously reported that the negative inotropic effects of hyperthermia (42 °C) on left ventricular (LV) mechanoenergetics using the excised, cross-circulated rat heart model. Here, we investigated the...

    Authors: Koji Obata, Hironobu Morita and Miyako Takaki
    Citation: The Journal of Physiological Sciences 2020 70:4
  4. The present study aimed to investigate whether endurance exercise-induced changes in blood plasma composition may lead to adaptations in erythrocytes, skeletal muscle and liver. Forty sedentary rats were rando...

    Authors: Georgios Goutianos, Nikos V. Margaritelis, Theodora Sparopoulou, Aristidis S. Veskoukis, Ioannis S. Vrabas, Vassilis Paschalis, Michalis G. Nikolaidis and Antonios Kyparos
    Citation: The Journal of Physiological Sciences 2020 70:3
  5. Fragrance inhalation of essential oils is widely used in aromatherapy, and it is known to affect blood pressure (BP) and heart rate (HR) via autonomic control of circulation. In this study, we aimed to test th...

    Authors: Eriko Kawai, Ryosuke Takeda, Akemi Ota, Emiko Morita, Daiki Imai, Yuta Suzuki, Hisayo Yokoyama, Shin-ya Ueda, Hidehiro Nakahara, Tadayoshi Miyamoto and Kazunobu Okazaki
    Citation: The Journal of Physiological Sciences 2020 70:2
  6. We hypothesized that cerebral blood flow (CBF) regulation in the posterior circulation differs from that of the anterior circulation during a cold pressor test (CPT) and is accompanied by elevations in arteria...

    Authors: Takuro Washio, Hironori Watanabe and Shigehiko Ogoh
    Citation: The Journal of Physiological Sciences 2020 70:1
  7. Distress vocalizations are fundamental for survival, and both sonic and ultrasonic components of such vocalizations are preserved phylogenetically among many mammals. On this basis, we hypothesized that ultras...

    Authors: Hirokazu Doi, Simone Sulpizio, Gianluca Esposito, Masahiro Katou, Emi Nishina, Mayuko Iriguchi, Manabu Honda, Tsutomu Oohashi, Marc H. Bornstein and Kazuyuki Shinohara
    Citation: The Journal of Physiological Sciences 2019 69:729
  8. Menopause is a risk factor for impaired glucose metabolism. Alternative treatment of estrogen for postmenopausal women is required. The present study was designed to investigate the effects of 5-week endurance...

    Authors: Mizuho Kawakami, Naoko Yokota-Nakagi, Akira Takamata and Keiko Morimoto
    Citation: The Journal of Physiological Sciences 2019 69:723
  9. Hypoglycemia-associated autonomic failure (HAAF) is a serious complication of diabetes which is associated with the absence of physiological homeostatic counter-regulatory mechanisms that are controlled by the...

    Authors: Bashair M. Mussa, Jalal Taneera, Abdul Khader Mohammed, Ankita Srivastava, Debasmita Mukhopadhyay and Nabil Sulaiman
    Citation: The Journal of Physiological Sciences 2019 69:718
  10. An atrial tachyarrhythmias is predominantly triggered by a proarrhythmic activity originate from the pulmonary veins (PV) myocardial sleeves; sympathetic or adrenergic stimulation facilitates PV proarrhythmia....

    Authors: V. M. Potekhina, O. A. Averina, A. A. Razumov, V. S. Kuzmin and L. V. Rozenshtraukh
    Citation: The Journal of Physiological Sciences 2019 69:724
  11. This brief review summarizes the current knowledge on sex differences in baroreflex function, with a major focus on studies in humans. It has been demonstrated that healthy women have blunted cardiovagal baror...

    Authors: Qi Fu and Shigehiko Ogoh
    Citation: The Journal of Physiological Sciences 2019 69:727
  12. The cardiovascular effects of the autonomic nervous system (ANS) are modulated by inputs from peripheral sensors and other brain regions. However, it currently remains unknown whether the manual acupuncture (M...

    Authors: Hidehiro Nakahara, Toru Kawada, Shin-ya Ueda, Eriko Kawai, Hiromi Yamamoto, Masaru Sugimachi and Tadayoshi Miyamoto
    Citation: The Journal of Physiological Sciences 2019 69:728
  13. When choosing the best action from several alternatives, we compare each value that depends on the balance between benefit and cost. Previous studies have shown that animals and humans with low brain serotonin...

    Authors: Fumika Akizawa, Takashi Mizuhiki, Tsuyoshi Setogawa, Mai Takafuji and Munetaka Shidara
    Citation: The Journal of Physiological Sciences 2019 69:725
  14. Increasing evidence demonstrates that electric stimulation has anticonvulsant effects. The present study was undertaken to investigate the effects of mild foot electrical stimulation (MFES) on the development ...

    Authors: Arefe Ghasemi-Dehno, Abolfazl Jand, Monir Abasi-Moghadam, Mehdi Sadegh, Morteza Mousavi-Hasanzadeh and Mohammad Reza Palizvan
    Citation: The Journal of Physiological Sciences 2019 69:726
  15. Mesenchymal stem cells (MSCs) are regarded as unique cells which play an imperative role in the field of regenerative medicine. They are characterized by the self-renewal capacity, multi-lineage differentiatio...

    Authors: Ramada R. Khasawneh, Ejlal Abu-El-Rub, Abdullah Omar Serhan, Bashar Omar Serhan and Hadeel Abu-El-Rub
    Citation: The Journal of Physiological Sciences 2019 69:720
  16. We aimed to identify the neurotransmitters and brain regions involved in exercise efficiency in mice during continuous complicated exercises. Male C57BL/6J mice practiced treadmill running with intermittent ob...

    Authors: Tetsuya Shiuchi, Takuya Masuda, Noriyuki Shimizu, Sachiko Chikahisa and Hiroyoshi Séi
    Citation: The Journal of Physiological Sciences 2019 69:722
  17. To investigate the exercise intensity effects on rats’ memory and learning, animals were divided into control, moderate training (MT), and overtraining (OT) groups. At training last week, learning and memory w...

    Authors: Zahra Jahangiri, Zahra Gholamnezhad, Mahmoud Hosseini, Farimah Beheshti and Narges Kasraie
    Citation: The Journal of Physiological Sciences 2019 69:719
  18. The aim of this study was to investigate the effect of activated ghrelin with dietary octanoic acids or medium-chain triglyceride (MCT) administration to underweight patient with chronic obstructive pulmonary ...

    Authors: Keisuke Miki, Seigo Kitada, Mari Miki, Shu-Ping Hui, Rojeet Shrestha, Kenji Yoshimura, Kazuyuki Tsujino, Hiroyuki Kagawa, Yohei Oshitani, Hiroshi Kida, Ryoji Maekura and Kenji Kangawa
    Citation: The Journal of Physiological Sciences 2019 69:716
  19. Expiratory (E) neurons in the caudal nucleus retroambigualis extend descending spinal axons to the lumbar and sacral spinal cord. Discharge rates of single E neurons were recorded to examine differences in act...

    Authors: Sei-Ichi Sasaki, Ken Muramatsu and Masatoshi Niwa
    Citation: The Journal of Physiological Sciences 2019 69:715
  20. Milk supply and quality during lactation are critical for progeny survival. Maternal tissues and metabolism, influenced by hormonal changes, undergo modification during lactation to sustain breastfeeding. Two ...

    Authors: Gustavo Canul-Medina and Cristina Fernandez-Mejia
    Citation: The Journal of Physiological Sciences 2019 69:714
  21. Diarrhea is a gastrointestinal symptom associated with systemic anaphylaxis and could be induced by increased colonic motility. We determined colonic motility and expulsion by measuring the intracolonic pressu...

    Authors: Tao Zhang, Toshishige Shibamoto, Mamoru Tanida, Yuhichi Kuda, Wei Yang and Yasutaka Kurata
    Citation: The Journal of Physiological Sciences 2019 69:710
  22. In the diabetic brain, hyperglycemia damages the cerebrovasculature and impairs neurovascular crosstalk. Calcitonin gene-related peptide (CGRP) is an important neuropeptide that is active in the vascular syste...

    Authors: Yanjun Guo, Qin Zhang, Huilu Chen, Yixuan Jiang and Ping Gong
    Citation: The Journal of Physiological Sciences 2019 69:708
  23. Motor units are generally recruited from the smallest to the largest following the size principle, while cutaneous stimulation has the potential to affect spinal motor control. We aimed to examine the effects ...

    Authors: Kotaro Tamura, Satoshi Sugita, Tadayuki Tokunaga, Yoshihiko Minegishi and Noriyasu Ota
    Citation: The Journal of Physiological Sciences 2019 69:707
  24. The vestibular system contributes to not only eye movement and posture but also the sympathetic response. Plastic alteration of the vestibulo-sympathetic reflex is induced by hypergravity load; however, the me...

    Authors: Chikara Abe, Yusuke Yamaoka, Yui Maejima, Tomoe Mikami and Hironobu Morita
    Citation: The Journal of Physiological Sciences 2019 69:705
  25. This study determined whether blockade of 5-hydroxytryptamine 2A (5-HT2A) receptors attenuated hyperthermia and tachycardia responses to psychological stress in mice. For this purpose, male mice (C57BL/6N) wer...

    Authors: Vanshika Sinh and Youichirou Ootsuka
    Citation: The Journal of Physiological Sciences 2019 69:703
  26. Exercise has an effect on the reduction of myocardial fibrosis in diabetic rats as previously reported, in which oxidative stress and the TGF-β1/Smad signaling pathway may play key roles. There is little direc...

    Authors: Shi-Qiang Wang, Dan Li and Yang Yuan
    Citation: The Journal of Physiological Sciences 2019 69:696
  27. We investigated the effect of muscle damage and inflammation on electrical resistance and the body composition assessment by using bioimpedance spectroscopy (BIS). Twenty-two subjects completed 30 repetitions ...

    Authors: Keisuke Shiose, Yoko Tanabe, Takahiro Ohnishi and Hideyuki Takahashi
    Citation: The Journal of Physiological Sciences 2019 69:702
  28. Intermittent claudication (IC) is the most common symptom of peripheral arterial disease which significantly deteriorates the quality of life of patients. Exercise training is by far the most effective treatme...

    Authors: Momoko Shiragaki-Ogitani, Keita Kono, Futoshi Nara and Atsushi Aoyagi
    Citation: The Journal of Physiological Sciences 2019 69:701
  29. In congestive heart failure (CHF), while resting parasympathetic activity becomes reduced, parasympathetically-mediated responses to stressors have not been described. This study aimed to (1) elucidate the eff...

    Authors: Satoshi Koba, Ichiro Hisatome and Tatsuo Watanabe
    Citation: The Journal of Physiological Sciences 2019 69:698
  30. Near-infrared spectroscopy (NIRS) has become an increasingly valuable tool to monitor tissue oxygenation (Toxy) in vivo. Observations of changes in the absorption of light with Toxy have been recognized as early ...

    Authors: Takafumi Hamaoka and Kevin K. McCully
    Citation: The Journal of Physiological Sciences 2019 69:697
  31. Serum testosterone concentration decreases with age in humans and rodents. Accordingly, old male mice show changes in locomotor activity rhythms: a lengthened free-running period and decreased activity levels ...

    Authors: Atsuyoshi Hashimoto, Shingo Fujiki, Wataru Nakamura and Takahiro J. Nakamura
    Citation: The Journal of Physiological Sciences 2019 69:695
  32. Intermittent hyperbaric oxygen exposure (IE-HBO) can protect the body against oxygen toxicity, but the underlying mechanisms are not very clear. Peroxiredoxin 6 (Prdx6) is a special endogenous antioxidative pr...

    Authors: Lichao Zhang, Yanan Zhang, Zhongzhuang Wang, Yuliang Chen and Runping Li
    Citation: The Journal of Physiological Sciences 2019 69:694
  33. The effects of a combination of the antioxidant astaxanthin (AX) and electrical stimulation (ES) on muscle mass and mitochondrial oxidative capacity were investigated in the soleus muscle of hindlimb unloaded ...

    Authors: Miho Kanazashi, Masayuki Tanaka, Ryosuke Nakanishi, Noriaki Maeshige and Hidemi Fujino
    Citation: The Journal of Physiological Sciences 2019 69:692
  34. The effects of the pharyngeal non-noxious mechanical stimulation on the secretion of immunoreactive thyroxin (iT4), immunoreactive calcitonin (iCT), and immunoreactive parathyroid hormone (iPTH) into thyroid v...

    Authors: Kaori Iimura, Harue Suzuki and Harumi Hotta
    Citation: The Journal of Physiological Sciences 2019 69:691
  35. Operant methods that allow animals to avoid painful stimuli are interpreted to assess the aversive quality of pain; however, such measurements require investigator-initiated stimuli to animals. Here we develop...

    Authors: Ken-ichiro Hayashida, James C. Eisenach, Masahito Kawatani and Thomas J. Martin
    Citation: The Journal of Physiological Sciences 2019 69:693
  36. We have previously reported that increased extracellular and intracellular Ca2+ lead to adipocyte accumulation in bone marrow stromal cells (BMSCs). However, strategies to suppress high Ca2+-enhanced adipocyte ac...

    Authors: Ryota Hashimoto, Yuki Miyamoto, Seigo Itoh, Hiroyuki Daida, Takao Okada and Youichi Katoh
    Citation: The Journal of Physiological Sciences 2019 69:690
  37. Nesfatin-1 is a hypothalamic anorexigenic peptide processed from nucleobindin 2 (NUCB2). Central and peripheral administration of NUCB2/nesfatin-1 enhances glucose metabolism and insulin release. NUCB2/nesfati...

    Authors: Yifei Yang, Boyang Zhang, Masanori Nakata, Jun Nakae, Masatomo Mori and Toshihiko Yada
    Citation: The Journal of Physiological Sciences 2019 69:689
  38. Besides the two canonical calciotropic hormones, namely parathyroid hormone and 1,25-dihydroxyvitamin D [1,25(OH)2D3], there are several other endocrine and paracrine factors, such as prolactin, estrogen, and ins...

    Authors: Kannikar Wongdee, Mayuree Rodrat, Jarinthorn Teerapornpuntakit, Nateetip Krishnamra and Narattaphol Charoenphandhu
    Citation: The Journal of Physiological Sciences 2019 69:688
  39. Our previous demonstration that severe experimental autoimmune encephalomyelitis (EAE) increases MnSOD protein abundance in the mouse kidney cortex led this study to elucidate the underlying mechanism with mon...

    Authors: Sharanpreet Hira, Balamuguran Packialakshmi and Xiaoming Zhou
    Citation: The Journal of Physiological Sciences 2019 69:687
  40. Endoplasmic reticulum (ER) stress is involved in inflammation-induced neurotoxicity. Mitofusin 2 (Mfn2), a member of the GTPase family of proteins, resides in the ER membrane and is known to regulate ER stress...

    Authors: Shu Hou, Lili Wang and Guoping Zhang
    Citation: The Journal of Physiological Sciences 2019 69:685
  41. A high-fat diet (HFD) and overweight status can induce hippocampal dysfunction, leading to depression and anxiety. Exercise has beneficial effects on emotional behaviors. We previously reported that exercise t...

    Authors: Yuki Tomiga, Saki Yoshimura, Song-Gyu Ra, Yuri Takahashi, Rina Goto, Ikumi Kugimoto, Yoshinari Uehara, Kentaro Kawanaka and Yasuki Higaki
    Citation: The Journal of Physiological Sciences 2019 69:686
  42. Silibinin has been shown to attenuate cognitive dysfunction and inhibit amyloid-beta (Aβ) aggregation in Alzheimer’s disease (AD) models. However, the underlying mechanism by which silibinin improves cognition...

    Authors: Dafeng Bai, Ge Jin, Dajun Zhang, Lini Zhao, Mingyue Wang, Qiwen Zhu, Lin Zhu, Yan Sun, Xuan Liu, Xueying Chen, Liqian Zhang, Wenbo Li and Yan Cui
    Citation: The Journal of Physiological Sciences 2019 69:682
  43. Japanese menopausal women who feel cold, even in a warm room, are said to be experiencing “hie-sho.” We assessed the magnitude of coldness by a “hie-sho” interview score. The association between the magnitude ...

    Authors: Yuki Uchida, Kyoko Ueshima, Koko Kano, Mayuko Minami, Yuri Mizukami and Keiko Morimoto
    Citation: The Journal of Physiological Sciences 2019 69:680
  44. Adequate oxygen supply by exposure to mild hyperbaric oxygen at appropriately high atmospheric pressure (1266–1317 hPa) and increased oxygen concentration (35–40% oxygen) has a possibility of improving the oxi...

    Authors: Akihiko Ishihara
    Citation: The Journal of Physiological Sciences 2019 69:678

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