Table 1 Summary of TRPV2 function and related disease
From: Physiological significance of TRPV2 as a mechanosensor, thermosensor and lipid sensor
Organ | Cells | Function | Related disease |
|---|---|---|---|
Brain | Neuron, astrocyte | Synaptic and glial transmission | Depression |
DRG | Neuron | Nociception | Pain |
Heart | Myocyte | Myocardial conduction | Cardiac hypertrophy |
Pancreas | β-Cells | Insulin secretion | Diabetes |
Intestine | Myenteric neuron | Intestinal motility | Irritable bowel syndrome |
Spleen | Macrophage, mast cell, lymphocyte | Immune response | Immunodeficiency |
Urinary bladder | Epithelial cell | Sensing stretch | Bladder cancer |
Prostate | Epithelial cell | LPC receptor | Prostate cancer |
Bone | Osteoclast | Calcium oscillation | Cancer |
Muscle | Skeletal and cardiac muscle cells | Sensing stretch | Muscular dystrophy |
Blood vessel | Smooth muscle, endothelial cell | Blood pressure control | Cardiomyopathy |