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To elucidate the significance of cytoskeletal microtubule networks in striated muscles, we analyzed correlation between the content of tubulin (building block of microtubules) and αB-crystallin (a molecular ch...
β-Phorbol esters (BPE), synthetic analogues of diacylglycerol (DAG), induce the potentiation of transmission in many kinds of synapses through activating the C1 domain-containing receptors. However, their effects...
The sino-atrial node (SAN) is the natural pacemaker of the heart. Mechanisms of the leading pacemaker site generation and dynamic pacemaker shifts in the SAN have been so far studied with an electrophysiologic...
Human serum albumin (HSA) is a mixture of mercaptalbumin (HMA, reduced form) and nonmercaptalbumin (HNA, oxidized form), i.e., a protein-thiol redox couple in the extracellular fluid (ECF), and it might have a...
Stimulation of the Na+–H+ exchanger plays an important role in the pathway of myocardial dysfunction and injury following hemorrhagic shock. Inhibition of the Na+–H+ exchanger appears to be a new pharmacological ...
Systems biology, particularly at the higher levels that are the domain of the Physiome Project, offers a more promising basis for constructive dialogue with traditional oriental medicine than does reductive mo...
The role of neuronal nitric oxide synthase (nNOS) in cardiac ischemia–reperfusion (IR) and ischemia preconditioning (IP) is still controversial. Here, we focused on the possible roles of nNOS in cardiac IR and...
Experimental data accumulated over the past decade show the emerging importance of the late sodium current (I NaL) for the function of both normal and, especially, failing myocardium, in w...
Bipolar and monopolar surface electromyography (sEMG) are known procedures to measure the H-reflex. However, signal cancellation is a potential experimental problem of bipolar sEMG. The results of our study sh...
Changes in the luminal NaCl concentration ([NaCl]) at the macula densa (MD) modulate the tubuloglomerular feedback (TGF) responses via an affect on the release of nitric oxide (NO). This study was performed in...
Increased oxidative stress resulting from enhanced production of reactive oxygen species and/or inadequate mechanisms of antioxidant defenses has been recognized as an important factor contributing to the init...
The Erratum to this article has been published in The Journal of Physiological Sciences 2013 63:s12576-012-0242-7
The skeletal muscle is one of the important target tissues for the actions of estrogen via both nuclear and extranuclear (non-genomic) pathways. However, there is a paucity of information about the receptor (E...
Massotherapy, the therapeutic use of massage, is used to treat various chronic pain syndromes. One type of massotherapy, pressure stimulus applied over trigger points (TPs), is reported to have excellent thera...
The pattern of respiratory activity in abdominal muscles was studied in anesthetized, spontaneously breathing, vagotomized neonatal rats at postnatal days 0–3. Anesthesia (2.0% isoflurane, 50% O2) depressed breat...
Cutaneous vascular responses to mental arithmetic (MA) and handgrip exercise (HG) were studied independently and combined at different local skin temperatures (T loc). MA and HG induced (P
Ultraviolet (UV) light-induced apoptosis has been extensively examined, but data on properties of intracellular water are insufficient. Thus, we examined the 1H spin-lattice relaxation time (T1) of intracellular ...
Litttle is known about the function of aquaporin (AQP) water channels in human gastric cancer. In the upper or middle part of human stomach, we found that expression level of AQP5 protein in intestinal type of...
It is unclear whether nitrous oxide (N2O) has a protective effect on cardiac function in vitro. In addition, little is known about the cardioprotective effect of anesthesia administered during hypoxia or ischemia...
This study was designed in order to consider whether the release of neuronally derived nitric oxide (NO) in the lumbosacral spinal cord during ischemia/reperfusion is region-specific and whether changes in Ca2+-d...
This article is part of a Supplement: Volume 59 Supplement 1
Chronic low blood pressure is typically accompanied by symptoms such as fatigue, reduced drive, dizziness, headaches and cold limbs. Reduced cognitive performance, diminished cerebral blood flow and autonomic ...
The currents through the volume-regulated outwardly rectifying anion channel (VRAC) were measured in single ventricular myocytes obtained from streptozotocin (STZ)-induced diabetic mice, using whole-cell volta...
Spikes are classified according to their finite differences in various orders. The fundamental idea that makes it work is that finite differences can extract and isolate features from spikes. This method showe...
Recent studies on the association between particular single nucleotide polymorphisms of serine–threonine kinase with no lysine (K) 4 gene (WNK4) and essential hypertension have yielded controversial results. Her...
The external work (EW) efficiency of individual arrhythmic beats of the left ventricle (LV) cannot directly be obtained since LV O2 consumption (VO2) of each beat cannot directly be measured under beat-to-beat va...
The goal of our study was to evaluate the origin of the increased O2 consumption in electrically stimulated left ventricular slices of isoproterenol-induced hypertrophied rat hearts with normal left ventricular p...
The maxi-anion channel is widely expressed and found in almost every part of the body. The channel is activated in response to osmotic cell swelling, to excision of the membrane patch, and also to some other p...
G-protein coupled receptors for the pineal hormone melatonin have been partially cloned from rats. However, insufficient information about their cDNA sequences has hindered studies of their distribution and ph...
To examine the age-related morphological changes in the motor endplate of type-identified muscle fibers, 20 male Wister rats were divided into 2-month-, 10-month-, 24-month- and 30-month-old groups (n = 5 in each...
We compared the prognostic power of end-tidal CO2 pressure (PETCO2) during exercise, an index of arterial CO2 pressure, with those of established respiratory gas indexes during exercise testing in patients with l...
Human ECG records were analyzed during supine (SUP) rest and whole body 80° head-up tilt (HUT), with a respiratory acidosis (5%CO2) and breathing room air (RA). HUT increased heart rate in both conditions (RASUP ...
Gastrin is important for stimulating acid secretion as well as differentiating gastric mucosal cells via cholecystokinin-2 receptors (CCK-2Rs). In turn, CCK acts preferably via CCK-1R to release somatostatin, ...
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