Fig. 7
Summary of results. A1 Caffeine-assisted oscillation was composed comprised an initial phase that is non-NMDA receptor dependent and a later oscillatory phase that is NMDA receptor dependent. A2 Application of baclofen attenuated the initial phase, and abolished the later oscillatory phase. Gray color area shows GABAB receptor-responsive components. Residual initial phase was non-NMDA receptor dependent. B Presumed downstream of GABAB receptor and NMDA receptor based on the present experiments. Application of caffeine induced oscillation via increase in NMDA receptor activity and CICR. Application of baclofen attenuated transmitter release at presynaptic site, and inhibited oscillatory phase via downregulation of NMDA receptor at postsynaptic site. Pharmacological actions of d-AP5 and thapsigargin are also illustrated. A1-R Adenosine A1 receptor, Ry-R ryanodine receptor, AC adenylyl cyclase