Fig. 2

Time dependent regulatory model of AH outflow rhythm by sympathetic nerve NE. Regulatory model of time-dependent systems in which nocturnal NE suppresses phagocytosis of trabecular meshwork (TM) macrophage to induce AH outflow resistance through β1-AR-EPAC-SHIP1 activation. This nocturnal activation suppresses phagocytic cup formation and triggers PIP3 expression on the cellular membrane, leading to an increase in the IOP at night. Genomic regulation by NE and the effects of NE and GCs on the cytoskeleton in the TM remain unknown. This figure is modified from a previous study [26]