Fig. 4

A, B Assessment of renal HMGB1 and downstream NF-κB under different conditions, HMGB1 (A) and NF-κB (B). Values are expressed as the mean ± SEM. ns: nonsignificant, **p < 0.01, ****p < 0.0001. C, D Pearson’s correlation and simple linear regression of pooled values of all different studied groups show a significant positive correlation between HMGB1 and urea (C). Significant positive correlation between HMGB1 and creatinine (D). n: number of values = 50, r: Pearson’s correlation coefficient