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Table 2 Physicochemical Halide Anion Selectivity Sequence

From: Physiology of the volume-sensitive/regulatory anion channel VSOR/VRAC. Part 1: from its discovery and phenotype characterization to the molecular entity identification

Eisenman type

Sequence

Corresponding anion channel

I (low-field)

I−  > Br−  > Cl−  > F−

VSOR/VRAC, ASOR/PAC, CaCC, Maxi-Cl

II

Br−  > I−  > Cl−  > F−

 

III

Br−  > Cl−  > I−  > F−

CFTR

IV

Cl−  > Br−  > I−  > F−

ClC-2

V

Cl−  > Br−  > F−  > I−

 

VI

Cl−  > F−  > Br−  > I−

 

VII (strong-field)

F−  > Cl−  > Br−  > I−

 
  1. VSOR/VRAC represents the volume-sensitive outwardly rectifying/volume-regulatory anion channel, ASOR/PAC the acid-sensitive outwardly rectifying/proton-activated anion channel, CaCC the Ca2+-activated chloride channel, Maxi-Cl the large-conductance maxi-anion channel, CFTR the cyclic AMP-activated cystic fibrosis transmembrane conductance regulator anion channel, and ClC-2 the voltage-gated chloride channel-2