Fig. 7
From: Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness
Modified from Murase et al. [88]
Involvement of GDNF in DOMS. a: Time course of change in GDNF mRNA expression in exercised muscle, * compared with the control (CTR). b: Photomicrograph of the in situ hybridization of GDNF mRNA. Dark field pictures (left) were taken from transverse sections at low magnification to show the mRNA signals (white dots) over a wide area. Bright field pictures (right) were taken from longitudinal sections to show the relationship between signals (black dots) and muscle cells. White arrows in bright fields photos indicate dense signals around the nuclei of muscle/satellite cells. c: GDNF mRNA upregulation was suppressed by COX-2 inhibitors (p.o.) prior to LC. * Compared to no drug treatment. d: Intramuscular injection of anti-GDNF antibody (10 μg) injected 2 days after LC reversed decreased withdrawal threshold. * Compared to pre-injection 2 days after LC.