Fig. 6
From: Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness
Modified from Murase et al. [37]
NGF-induced mechanical sensitization of muscular thin-fiber receptors. Single-fiber recordings were performed from the common peroneal nerve-extensor digitorum longus muscle preparation ex vivo. a: Sample recordings from C-fibers before and 120Â min after intramuscular injection of PBS (left) and NGF (right) near the receptive field. The mechanical response of the fibers that received the NGF injection increased 120Â min after NGF injection. b: Time course of the change in the response threshold to ramp mechanical stimulation after injection. c: Time course of the change in the response magnitude (no. of discharges induced by ramp mechanical stimulation) after the injection. * Compared with the PBS group at each time point.