Fig. 5
From: Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness
Modified from Murase et al. [37]
B2 bradykinin receptor–NGF route in DOMS. a: Dark-field (left) and bright-field (right) photomicrographs of in situ hybridization on the LC side (left pair) and contralateral side (right pair). White dots in bright-field photos and black dots in bright-field photos represent signals of in situ hybridization of NGF mRNA. Signals were observed around myofiber/satellite cell nuclei in LC side. b: Injection of anti-NGF antibody (30 μg) into the muscle at the time point marked with a symbol of injector almost completely reversed the decreased withdrawal threshold in 3 h (#). c: NGF dose-dependently decreased the withdrawal threshold 2 or 3 h after injection. Comparison was made with – 1 day.