Fig. 13
From: Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness
Modified from Urai et al. [132]
DOMS is attenuated by repeated LC. a: A Decrease in MMWT after LC did not occur after the second bout of LC with a 5-day-interval. b: NGF mRNA increased after 1st LC but not after 2nd LC, corresponding to the absence of DOMS after 2nd LC. c: Subcutaneous injection of the B2 receptor antagonist HOE140 before 1st LC suppressed DOMS not only after 1st LC but also after 2nd LC, although the effect of HOE 140 lasts for several hours. Consistent with this observation, NGF mRNA levels did not increase in either group (d). These results suggest that adaptation to LC occurs prior to B2 bradykinin receptor activation.