Fig. 11
From: Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness
Modified from Matsubara et al. [126]
Mechanical sensitization of thin-fiber receptors after LC is mediated by ASIC3. Single-fiber recordings from Aδ- and C-fibers were performed from the common peroneal nerve-extensor digitorum longus muscle preparation ex vivo. Average time histograms of the mechanical responses of Aδ- (a) and C-fibers (b) from control rats and rats that underwent LC. Thus, the response of the LC group was facilitated. The ASIC3 inhibitor APETx2 (2.2 μM) injected near the receptive field reversed the decreased mechanical threshold (left) and increased the response magnitude (right) of both Aδ- (c) and C-fibers (d).