Table 1 Transport properties of urate transporters expressed in renal proximal tubular regions of human males in this analysis
From: Identification of three distinct cell populations for urate excretion in human kidneys
SLC name | Protein name | Function | Type | Transport system* | Substrates* | Av. (PT_S1) | Av. (PT_S2) | Av. (PT_S3) | Av. (LOH (DL)) | Km for urate (μM) | Refs. |
|---|---|---|---|---|---|---|---|---|---|---|---|
SLC22A11 | OAT4 | Reabsorption | AI | Exchanger/Facilitate | Organic anions (e.g., NSAIDs, PG, urate) | 2.99 | 3.97 | 4.52 | 1.94 | 3779.6 | Hagos et al., 2007 |
SLC22A12 | URAT1 | Reabsorption | AI | Exchanger | Urate | 0.36 | 0.92 | 1.42 | 0.70 | 371 | Enomoto et al., 2002 |
SLC2A9 | GLUT9 | Reabsorption | BE | Facilitate | Urate (glucose, fructose) | 4.68 | 4.53 | 7.35 | 5.47 | 365 | Anzai et al., 2008 |
SLC22A6 | OAT1 | Secretion | BI | Exchanger | Organic anions (e.g., PAH, PG, urate) | 10.25 | 12.93 | 12.50 | 1.50 | 943 | Ichida et al., 2003 |
SLC22A7 | OAT2 | Secretion | BI | Exchanger/Facilitate | Organic anions (e.g., PAH, PG, urate) | 1.29 | 1.91 | 4.74 | 0.79 | 1168 | Sato et al., 2010 |
SLC22A8 | OAT3 | Secretion | BI | Exchanger | Organic anions (e.g., PAH, PG, urate) | 3.75 | 2.96 | 3.13 | 1.25 | 2888 | Bakhiya et al., 2003 |
SLC17A1 | NPT1 | Secretion | AE | Facilitate (Δψ-driven/Cl−-dependent) | Organic anions (e.g., PAH, urate) | 10.60 | 8.54 | 7.66 | 5.89 | 1100 | Iharada et al., 2010 |
SLC17A3 | NPT4 | Secretion | AE | Facilitate (Δψ-driven) | Organic anions (e.g., PAH, urate) | 6.02 | 3.82 | 3.56 | 2.18 | Unknown | Jutabha et al., 2010 |