Fig. 5
From: Identification of three distinct cell populations for urate excretion in human kidneys
Major cell populations explaining renal urate transport dynamics. A CUTE model represents cell populations that contributed to urate reabsorption and secretion. Colors indicate types of transporters: red, AI or BE transporters; blue, BI or AE transporters Arrows indicate directions of urate flow. B Bar plot showing cell proportion by cellular urate handling in three PT segments and LOH (DL) regions. C Schematic diagram illustrating the feasibility of the superiority of urate reabsorption over urate secretion. Left panel: attenuation of urate secretion in BIP cell population by SLC2A9 at all tubular regions. Right panel: reversibility of the transporter function between urate influx and efflux in human kidneys