Fig. 4

Expression profiles of urate transporters and PDZK1 in DIP cell population. A Expression levels and frequencies of PDZK1 in the cell populations. B Expression levels and frequencies of PDZK1 in the DIP cell population are rearranged by the numbers of apical membrane transporters. C Dot plot indicates the frequency and expression levels of the apical transporters (x-axis) across the positivity of PDZK1 (y-axis). Dot sizes refer to the frequency of a molecule expressed in the cell population (%Exp), while dot colors indicate the average expression levels of clusters (Avg Exp). D Proportions of the DIP cell population which express the numbers of BI transporters and PDZK1. y-axis, percentage of cells; x-axis, positivity of PDZK1 (Neg, negative; Pos, positive). E Proportions of the DIP cell population which express different types of efflux transporters and PDZK1. Y-axis, percentage of cells; x-axis, positivity of PDZK1 (Neg, negative; Pos, positive). F Schematic diagram of transporter reversibility from influx transporters to efflux transporters in the DIP cell population which did not express any efflux transporters. The apical membrane is to the left of the cells and the basolateral membrane is to the right of the cells. Red symbols represent the AI and BE transporters. Blue symbols represent the BI and AE transporters. Arrows indicate directions of urate flow