Fig. 2

Histological images of cardiac muscle sections of WT and EDMD model mice. A H&E images showing an increase in the interstitial space between cardiomyocytes, and unevenly stained areas of SDH and COX in cardiac sections from H222P and EH mice at 30 weeks of age but not from Emd mice. Scale bar represents 100 µm. B Graphs represent the percentage of SDH-stained or COX-stained area normalized by the area of H&E stained cardiac muscle from serial sections (n = 3 for WT and Emd mice, and n = 4 for H222P and EH mice). ***P < 0.001 versus WT mice at 30 weeks of age