Fig. 1

Typical example of the effect of AM404 on the slow ventral root potential (sVRP) in newborn rat spinal cord preparations. A Time course of the changes in peak amplitude of the sVRP in response to the application of 10 µM AM404. B Examples of the reflex response in the control (a), at 15 min after the administration of AM404 (b), and after 15 min of washout (c). a–c correspond to a-c in panel A. C Example showing a decrease in sVRP amplitude during the application of AM404 and an increase after washout. D Data plots of the sVRP amplitude from 10 preparations at control (black), 15 min application of AM404 (red), and 15 min after washout (blue). Bars on the right side of the individual datasets denote the mean ± S.D. The average values of the sVRP amplitude did not change significantly