Table 1 Reproted roles of Orai1-mediated signaling pathway in cancer
From: Physiological functions of calcium signaling via Orai1 in cancer
Cancer type | Reported functions | Orai1 expression (compared to normal cells or tissues) | Proposed effector pathway(s) | Pathophysiologic process | Inhibitors/knockdown effect | References [No.] |
|---|---|---|---|---|---|---|
Oral cancer | Tumorigenicity, tumor sphere formation, proliferation, migration, stemness | Protein↑ | NFAT; Lamin B | SOCE | Dominant negative Orai1 mutant (E106Q); Ectopic Orai1 expression | Lee et al. [9] |
Migration, proliferation, colony formation | mRNA↑; protein↑ | Akt; mTOR; NF-κB; CXCR4; MMP-9 | SOCE | 2-APB; LaCl2; SKF96365; siRNA | Singh et al. [13] | |
Migration/metastasis | N.D | PI3K; ERK; calpain; α-spectrin; MMP-2; MMP-9 | Ca2+ influx | YM58483; shRNA | Osawa et al. [12] | |
Proliferation, migration, invasion, clinical histopathological features | mRNA↑; protein↑ | N.D | N.D | siRNA | Wang et al. [14] | |
Melanoma | Migration/metastasis, proliferation (in part) | Protein↑ | ERK; CaMKII; Raf-I; MEK; α-spectrin; calpain | SOCE | YM58483; shRNA | Umemura et al. [7] |
Invadopodium formation, invasion, metastasis | Protein↑ | Src | Ca2+ oscillations | SKF96365; 2-APB; A23187; shRNA | Sun et al. [36] | |
Proliferation, Migration, invasion | Protein↑ | MITF; JARID1B; Brn2 | SOCE | 2-APB; siRNA | Stanisz et al. [8] | |
Invasion, metastasis, metabolism | N.D | Glycolysis; cholesterol | UV-induced SOCE | YM58483; UV2; UV5 | Gross e al. [22] | |
Breast cancer | Development, proliferation | mRNA↑ | N.D | SOCE | 2-APB; siRNA | McAndrew et al. [19] |
Migration, invasion, attachment, angiogenesis | N.D | Notch1/ NFAT4 | Hypoxia | SKF96365; DAPT; shRNA | Liu et al. [38] | |
EMT | N.D | Vimentin | SOCE | YM58483; EGTA; Cyto D; siRNA | Stewart et al.[25] | |
Glioblastoma | Invasion, proliferation | mRNA↑(in part) | N.D | SOCE; CRAC currents | siRNA | Motiani et al. [15] |
Cervical cancer | Proliferation, colony formation, tumor growth | mRNA↑; protein↑ | IL-6 | SOCE | SKF96365; AnCoA4 | Pan et al. [16] |
Multipe myeloma | Proliferation, cell cycle, apoptosis, clinical outcome | mRNA↑; protein↑ | N.D | SOCE | SKF96365; DES; 2-APB; siRNA | Wang et al. [17] |
Colorectal cancer | EMT, migration, clinical outcome | Protein↑ | E-cadherin; N-cadherin; Vimentin; calpain; TGF-β1 | SOCE | shRNA; 2-APB | Kang et al. [18] |
Pancreatic stellate cell | Proliferation, cell cycle | N.D | Akt; TGF-β1 | SOCE | LY294002; siRNA | Radoslavova et al. [20] |