Fig. 3
The baroreflex equilibrium diagram was obtained by plotting the fitted neural and peripheral arcs on the pressure–SNA plane (a). The SNA–RVR relationship was quantified using linear regression (b). For the CSP–CVP (c) and CSP–RBF (d) relationships, the minimum, maximum, and mean values were examined because the relationships were not consistent across the rats. Data were obtained during the baseline (BL) period and after empagliflozin administration (T1, T2, and T3 periods). AP: arterial pressure; CSP: carotid sinus pressure; CVP: central venous pressure; RBF: renal blood flow; RVR: renal vascular resistance; SNA: sympathetic nerve activity; op-SNA and op-AP represent the operating-point SNA and AP, respectively; b0 and b1 represent the intercept and slope of linear regression, respectively. Data points show mean ± standard error values (n = 9 post-myocardial infarction rats) with parameters of respective rats illustrated in gray lines. The P values in the parentheses represent the results of one-way repeated-measures analysis of variance. *P < 0.05 and **P < 0.01 relative to BL by the post hoc Dunnett’s test