Fig. 2
Static characteristics of the baroreflex total arc (a), HR control (b), and neural arc (c) were analyzed using a four-parameter logistic function. Static characteristics of the baroreflex peripheral arc (d) were analyzed using linear regression. Data were obtained during the baseline (BL) period and after empagliflozin administration (T1, T2, and T3 periods). AP: arterial pressure; CSP: carotid sinus pressure; HR: heart rate; SNA: sympathetic nerve activity; P1, P2, P3, and P4 represent the response range, slope coefficient, midpoint pressure, and lower asymptote of the sigmoid curve, respectively (Eq. 1); b0 and b1 represent the intercept and slope of linear regression, respectively (Eq. 2). Data points show mean ± standard error values (n = 9 post-myocardial infarction rats) with parameters of respective rats illustrated in gray lines. The P values in the parentheses represent the results of one-way repeated-measures analysis of variance. **P < 0.01 relative to BL by the post hoc Dunnett’s test