Fig. 1

Blood glucose and plasma insulin levels after oral ingestion of glucose in wild-type and T1R3-GFP-knockout mice. A Blood glucose levels before and 5, 10, 30, 60, and 90 min after oral ingestion of glucose (2 mg/g body weight) in wild-type (WT) mice (n = 12) and T1R3-GFP-knockout (KO) mice (n = 6). B Plasma insulin levels before and 5, 10, 30, 60, and 90 min after oral ingestion of glucose (2 mg/g body weight) in WT mice (n = 9) and T1R3-GFP-KO mice (n = 6). Data are presented as the mean ± standard error. C, D Plasma insulin levels at 0 and 5 min after oral glucose (OG) ingestion (2 mg/g body weight) in WT mice (C) and T1R3-GFP-KO mice (D). E Changes in plasma insulin levels 5 min after glucose ingestion for WT and T1R3-KO mice. In these box plots, the box indicates the 25th and 75th percentiles; line across the box, the median; square, the mean; and whiskers, maximum and minimum values. Each point indicates individual data. **P < 0.01, paired t-test. NS not significantly different, Student’s t-test