Vidarabine, an anti-herpes agent, improves Porphyromonas gingivalis lipopolysaccharide-induced cardiac dysfunction in mice

Table 1 Cardiac function assessed by echocardiography at 1 week after PG-LPS

	Control	LPS	Vid	LPS + Vid
n	6	7	6	6
EF	67 ± 1.0	61 ± 0.9**	66 ± 4.7^##	67 ± 1.4^#
EDV	0.23 ± 0.01	0.21 ± 0.01	0.22 ± 0.03	0.21 ± 0.01
ESV	0.08 ± 0.004	0.08 ± 0.005	0.08 ± 0.02	0.07 ± 0.006
%FS	32 ± 0.8	28 ± 0.6**	32 ± 3.1^##	32 ± 0.9^#
LVIDd	4.51 ± 0.08	4.37 ± 0.08	4.47 ± 0.22	4.41 ± 0.08
LVIDs	3.1 ± 0.06	3.1 ± 0.07	3.1 ± 0.24	3.0 ± 0.08
HR	420 ± 35	443 ± 27	441 ± 40	406 ± 42
SV	0.15 ± 0.008	0.13 ± 0.005*	0.15 ± 0.02	0.14 ± 0.007
CO	60 ± 7.0	52 ± 3.1	61 ± 9.8	57 ± 4.5
IVSTd	0.5 ± 0.03	0.5 ± 0.04	0.5 ± 0.04	0.5 ± 0.04
LVSTs	0.96 ± 0.07	0.91 ± 0.07	0.91 ± 0.03	0.94 ± 0.05
LVPWTd	0.52 ± 0.03	0.52 ± 0.02	0.53 ± 0.05	0.52 ± 0.03
LVPWTs	0.96 ± 0.04	0.88 ± 0.03*	0.93 ± 0.08	0.89 ± 0.04

EF (%): left ventricular ejection fraction; EDV (mL): left ventricular end-diastolic volume; ESV (mL): left ventricular end-systolic volume; %FS: % fractional shortening; LVIDd (mm): left ventricular internal dimension at end-diastole; LVIDs (mm): left ventricular internal dimension at end-diastole; HR (bpm): heart rate; SV (mL): stroke volume; CO (mL/min): cardiac output; IVSTd (mm): interventricular septum thickness at end-diastole. LVSTs (mm): interventricular septum thickness at end-systole; LVPWTd (mm): left ventricular posterior wall thickness at end-diastole. LVPWTs (mm): left ventricular posterior wall thickness at end-diastole
**P < 0.01 vs. Control, *P < 0.05 vs. Control ^##P < 0.01 vs. LPS; ^#P < 0.05 vs. LPS

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