Fig. 2

Effects of vidarabine on PG-LPS-induced fibrosis in the heart. a Representative images of Masson-trichrome-stained sections of cardiac muscle in the Control (upper left), PG-LPS (upper right), vidarabine (lower left), and BO + vidarabine (lower right) groups. Scale bar: 100 μm. b The area of fibrosis was significantly increased in the PG-LPS group (n = 7, **P < 0.01), but this increase was blocked in the PG-LPS + vidarabine group (n = 6, **P < 0.01). One-way ANOVA followed by Tukey’s post hoc test). c Expression of α-SMA, a fibrosis-related gene, was significantly increased in the cardiac muscle of PG-LPS group (n = 5, **P < 0.01), but this increase was blocked in the cardiac muscle of PG-LPS + vidarabine group (n = 5, *P < 0.05). One-way ANOVA followed by Tukey’s post hoc test). Full-size images of immunoblots are presented in Additional file 1: Fig. S1. Data are presented as mean ± SD and scattered dots show individual data