Fig. 1

Protein–protein network construction and social network analysis. A The heatmap plot of significant genes with differential expression demonstrated the comparison of gene expression of healthy subjects to adult diabetic patients with dyslipidemia considering P.value < 0.001 thresholds. B Construction of the protein–protein interactions network of significant differential expressions involved in adult diabetic dyslipidemia status considering the visualizing parameters of the network. In this network, genes were ranked based on degree and betweenness centrality. The most prominent node indicated a higher degree, and the orange indicated genes with the highest betweenness centrality. IL-6 and ADIPOQ are the master regulatory cut-point genes as druggable candidates for pharmacological approaches and modulating pathogenesis networks in this network