Fig. 6

The coadministration of baclofen and saclofen to the GP has no effects on RTn neurons. A Left: Frequency histogram of one RTn neuron firing activity after coadministration of baclofen (300 ng) and saclofen (300 ng) in the GP. The horizontal yellow line represents the injection period. Right: Spiking rate of RTn neurons under basal conditions and after pharmacological stimulation by coadministration of baclofen and saclofen. The firing rate of RTn cells after local coinjection did not differ from the basal values; p = 0.79, paired t test; n = 12 neurons). B The plot summarizes the response of the RTn under all application conditions. The effects are expressed as percent changes relative to the basal activity