Table 2 Parameters relating to baroreflex open-loop static characteristics during baseline and T3 periods obtained in the empagliflozin group
Baseline | Empagliflozin | P value | |
|---|---|---|---|
Total reflex arc | |||
P1, mmHg | 64.2 ± 7.5 | 64.0 ± 4.9 | 0.982 |
P2, mmHg−1 | 0.106 ± 0.010 | 0.111 ± 0.016 | 0.832 |
P3, mmHg | 139.9 ± 3.5 | 140.5 ± 2.8 | 0.877 |
P4, mmHg | 78.1 ± 5.9 | 81.2 ± 5.0 | 0.282 |
Gmax, mmHg/mmHg | 1.66 ± 0.24 | 1.78 ± 0.30 | 0.779 |
HR control | |||
P1, beats/min | 68.8 ± 9.6 | 60.7 ± 7.1 | 0.271 |
P2, mmHg−1 | 0.106 ± 0.008 | 0.116 ± 0.008 | 0.324 |
P3, mmHg | 148.1 ± 2.8 | 144.9 ± 3.4 | 0.367 |
P4, beats/min | 395.0 ± 17.4 | 388.5 ± 11.2 | 0.504 |
Gmax, beats·min−1·mmHg−1 | 1.82 ± 0.25 | 1.72 ± 0.15 | 0.642 |
Neural arc | |||
P1, % | 44.7 ± 6.3 | 44.7 ± 9.6 | 0.998 |
P2, mmHg−1 | 0.145 ± 0.027 | 0.167 ± 0.031 | 0.667 |
P3, mmHg | 138.1 ± 6.7 | 139.2 ± 3.9 | 0.810 |
P4, % | 57.3 ± 6.4 | 49.1 ± 6.7 | 0.090 |
Gmax, %/mmHg | 1.51 ± 0.19 | 1.85 ± 0.43 | 0.351 |
Peripheral arc | |||
b0, mmHg | 5.0 ± 9.3 | 8.3 ± 16.7 | 0.820 |
b1, mmHg/% | 1.320 ± 0.115 | 1.527 ± 0.223 | 0.344 |
Operating point | |||
SNA, % | 92.0 ± 2.5 | 85.2 ± 9.2 | 0.457 |
AP, mmHg | 125.7 ± 4.2 | 130.3 ± 2.4 | 0.224 |