Fig. 5

The relationships of normalized urine flow (nUF) versus arterial pressure (AP) during baseline (BL), T1, T2, and T3 periods obtained in the vehicle (a) and empagliflozin (b) groups. The top panels show mean ± SE values with linear regression lines. In the middle panels, nUF-intercept indicates the intercept of the AP–nUF relationship. In the bottom panels, nUF-slope indicates the slope of the AP–nUF relationship. For nUF-intercept and nUF-slope, the data are presented as mean ± SE values with data points of the respective rats (n = 7 rats each). In each panel, the P value of the repeated-measures one-way analysis of variance (ANOVA) is shown in the parenthesis. The value is italicized when P < 0.05. Symbols * and *** indicate P < 0.05 and P < 0.001 from BL by the post hoc Dunnett’s test