Fig. 4
The upper panels illustrate the urine creatinine concentration during baseline (BL), T1, T2, and T3 periods obtained in the vehicle (a) and empagliflozin (b) groups. The lower panels illustrate the creatinine clearance (Ccr) for a single kidney during BL, T1, T2, and T3 periods obtained in the vehicle (c) and empagliflozin (d) groups. Data are presented as mean ± SE values with data points of the respective rats (n = 7 rats each). In each panel, the P value of the repeated-measures one-way analysis of variance (ANOVA) is shown in the parenthesis. The value is italicized when P < 0.05. Symbols * and *** indicate P < 0.05 and P < 0.001 from BL by the post hoc Dunnett’s test