Transporter-dependent uptake and metabolism of myocardial interstitial serotonin in the rat heart

Table 1 Time course of heart rate and mean arterial pressure

HR (bpm)	Baseline 1	Ringer 7.5 min	Ringer 22.5 min	Ringer 37.5 min	Ringer 52.5 min	Baseline 2	Parg 7.5 min	Parg 22.5 min	Parg 37.5 min	Parg 52.5 min	Parg 67.5 min	Parg 82.5 min
Fluo + Parg	342 ± 40	349 ± 36	352 ± 35	353 ± 35	352 ± 33	352 ± 33	351 ± 31	349 ± 31	348 ± 31	349 ± 30	350 ± 31	350 ± 31
D22 + Parg	344 ± 26	351 ± 24	355 ± 20	354 ± 22	353 ± 23	351 ± 24	348 ± 22	346 ± 20	346 ± 19	347 ± 18	349 ± 18	349 ± 19
Fluo + D22 + Parg	341 ± 25	348 ± 25	352 ± 23 *	354 ± 22 *	354 ± 22 *	353 ± 22 *	350 ± 21	348 ± 20	347 ± 21	346 ± 23	347 ± 24	347 ± 25

MABP (mmHg)	Baseline 1	Ringer 7.5 min	Ringer 22.5 min	Ringer 37.5 min	Ringer 52.5 min	Baseline 2	Parg 7.5 min	Parg 22.5 min	Parg 37.5 min	Parg 52.5 min	Parg 67.5 min	Parg 82.5 min
Fluo + Parg	95 ± 27	96 ± 24	97 ± 22	95 ± 19	94 ± 18	94 ± 20	92 ± 17	91 ± 16	91 ± 16	91 ± 15	92 ± 15	92 ± 14
D22 + Parg	99 ± 18	99 ± 17	99 ± 15	96 ± 16	94 ± 16	92 ± 16	90 ± 16*	89 ± 14*	89 ± 14*	89 ± 14*	90 ± 14*	90 ± 13*
Fluo + D22 + Parg	99 ± 23	99 ± 19	98 ± 18	97 ± 15	96 ± 15	94 ± 14	91 ± 13	90 ± 13	88 ± 13*	88 ± 14*	89 ± 15	89 ± 14

Values are shown in mean ± SD (n = 7). Effects of local administration of fluoxetine (Fluo), decynium-22 (D22), and Fluo + D22 co-administered with pargyline (Parg) on heart rate (HR) and mean arterial blood pressure (MABP) were compared by one-way repeated measures ANOVA followed by Tukey's multiple comparison tests
^*p < 0.05 vs baseline 1

ISSN: 1880-6562