Fig. 7

Effects of minocycline (MINO) on ventilatory responses to mild (13% O₂) (A) and severe (7% O₂) (B) hypoxia. To evaluate response magnitudes of minute ventilation, Δ\({\dot {\text V}} \)e was calculated for the hypoxia-baseline and recovery-baseline differences. Δ\({\dot {\text V}} \)e was significantly larger in hypoxia than in recovery (** p < 0.01). There was a significant main effect between the two MINO conditions (F(1,5) = 16.78, p < 0.01) meaning that Δ\({\dot {\text V}} \)e was, as overall, smaller in the MINO treated than untreated condition across all oxygen phases. The hypoxia-baseline Δ\({\dot {\text V}} \)e in the control MINO-untreated condition tended to be higher than that in the MINO-treated one in both mild and severe hypoxia, but the differences were statistically insignificant. * p < 0.05, ** p < 0.01