Table 3 Effect of tolfenamic acid on oxidative damage (lipid peroxidation, nitric oxide, superoxide dismutase and catalase levels) in the striatum of malonic acid injected rats
Group | MDA (nmol/mg protein) | NO (μmol/mg protein) | H2O2 (μmol/mg protein) | SOD (U/mg protein) | CAT (U/mg protein) |
|---|---|---|---|---|---|
Sham | 9.49 ± 0.88 | 0.54 ± 0.04 | 9.05 ± 1.24 | 54.66 ± 5.11 | 15.53 ± 1.71 |
MA | 16.37 ± 1.37c | 1.43 ± 0.07c | 15.60 ± 1.50c | 37.04 ± 2.28 | 8.89 ± 1.13c |
TA 8 mg/kg | 13.98 ± 1.20 | 1.17 ± 0.11a | 13.70 ± 1.46 | 41.63 ± 2.08 | 11.77 ± 1.67 |
TA 32 mg/kg | 10.49 ± 1.21b | 0.54 ± 0.06b | 9.77 ± 1.71a | 48.37 ± 1.97a | 14.32 ± 1.18a |