Fig. 4

Effect of tolfenamic acid on p53 and the posttranslational modification of p53 in the striatum of malonic acid-injected rats. There was no significant difference in the expression of p53 protein (A, B) or mRNA (C). Malonic acid injection decreased the level of p-p53 Ser378 (D) and increased the levels of Ac-p53 Lys370 (E) and Ac-p53 Lys382 (F). Tolfenamic acid prevented the malonic acid-induced changes in p-p53 Ser378 and Ac-p53 Lys382. All results are expressed as the mean ± SEM. WB: n = 5; mRNA: n = 3. #p < 0.05, ##p < 0.01 vs. sham; *p < 0.05, **p < 0.01 vs. MA