Fig. 3

Tolfenamic acid significantly decreased the expression of Nox1 in the striatum of malonic acid-injected rats. Immunohistochemical staining of Nox1 revealed increased Nox1 expression in the striatum of the malonic acid-injected rats and a significant decrease after tolfenamic acid treatment (A, B). Similar results were observed in the western blot analysis (C, D). All results are expressed as the mean ± SEM. n = 4. Scale bars = 250 μm. ##p < 0.01 vs. sham; *p < 0.05, **p < 0.01 vs. MA