Effects of continuous hypoxia on flow-mediated dilation in the cerebral and systemic circulation: on the regulatory significance of shear rate phenotype

Table 1 Cardiopulmonary responses

	Time	2 h			4 h			6 h				P values
	Inspirate	Eupnea	Hypercapnia	Δ	Eupnea	Hypercapnia	Δ	Eupnea	Hypercapnia	Δ		Time	Inspirate	Interaction
HR (bpm)	Normoxia	54 ± 13	53 ± 11	− 1 ± 2	57 ± 13	59 ± 12	2 ± 3	57 ± 10	60 ± 12	4 ± 6	Normoxia	0.019	0.138	0.126
	Hypoxia	62 ± 11	60 ± 10	− 3 ± 8	68 ± 19	68 ± 13	1 ± 11	72 ± 16	69 ± 12	− 3 ± 7	Hypoxia	0.035	0.577	0.868
											Δ	0.350	0.206	0.596
MAP (mmHg)	Normoxia	94 ± 12	99 ± 15	5 ± 5	93 ± 7	97 ± 5	4 ± 3	92 ± 7	95 ± 9	3 ± 5	Normoxia	0.830	0.069	0.906
	Hypoxia	84 ± 6	85 ± 3	2 ± 7	78 ± 9	78 ± 8	0 ± 6	81 ± 13	85 ± 12	4 ± 3	Hypoxia	0.097	0.420	0.806
											Δ	0.716	0.232	0.458
P_ETCO₂ (mmHg)	Normoxia	44 ± 7	51 ± 6	7 ± 2	44 ± 7	52 ± 6	8 ± 2	44 ± 3	51 ± 3	7 ± 1	Normoxia	0.634	< 0.001	0.952
	Hypoxia	37 ± 6	45 ± 3	8 ± 3	37 ± 5	44 ± 4	6 ± 3	33 ± 5	42 ± 4	9 ± 3	Hypoxia	0.010	< 0.001	0.387
											Δ	0.533	0.572	0.123

Values are mean ± SD
HR heart rate MAP mean arterial blood pressure, P_ETCO₂ end-tidal partial pressure of carbon dioxide
Bold p-values denote a P-value <0.05. The Bold has now been removed

ISSN: 1880-6562