Fig. 1

Hsa_circ_0000345 overexpression repressed cell proliferation, migration and invasion of SUNE1 cells, and hsa_circ_0000345 knockdown promoted cell proliferation, migration and invasion of 6-10B cells. A QRT-PCR was performed to detect the expression of hsa_circ_0000345 in NP69, SUNE1, HONE1, 6-10B and HNE1 cells. SUNE1 cells were transfected with pcDNA3.1-hsa_circ_0000345 or pcDNA3.1-NC. 6-10B cells were transfected with Si-hsa_circ_0000345 or Si-NC. B, C QRT-PCR was performed to assess the expression of hsa_circ_0000345 in the transfected SUNE1 and 6-10B cells. D, E MTT assay was performed to examine cell proliferation of the transfected SUNE1 and 6-10B cells. (F-K) Transwell assay was performed to estimate cell migration and invasion of the transfected SUNE1 and 6-10B cells. **P < 0.01 vs. NP69; ^##P < 0.01 vs. Vector; ^$$P < 0.01 vs. Si-NC