Fig. 5

Effect of vidarabine on AC5, NOX4/2, XO, phospho-p38 and phospho-ASK1 in the heart of BO mice. a AC5 expression was similar in all four groups. NS, not significantly different, by one-way ANOVA followed by the Tukey–Kramer post hoc test. Full-size images of immunoblots are presented in Additional file 1: Fig. S7. b NOX4 expression was significantly increased in the BO group (n = 8), and this increase was significantly blocked in the BO + V group (n = 8). ^**P < 0.01, ^***P < 0.001 by one-way ANOVA followed by the Tukey–Kramer post hoc test. Full-size images of immunoblots are presented in Additional file 1: Fig. S8. c NOX2 expression was similar among the four groups (n = 5 each). NS, not significantly different, by one-way ANOVA followed by the Tukey–Kramer post hoc test. Full-size images of immunoblots are presented in Additional file 1: Fig. S9. d Expression of XO was significantly increased in the BO group (n = 5), and this increase was significantly blocked in the BO + V group (n = 7). ^**P < 0.01, ^***P < 0.001, ^***P < 0.001 by one-way ANOVA followed by the Tukey–Kramer post hoc test. Full-size images of immunoblots are presented in Additional file 1: Fig. S10. e Expression of phospho-p38 was significantly increased in the BO group (n = 4) and this was significantly blocked in the BO + V group (n = 5). ^*P < 0.05 by one-way ANOVA followed by the Tukey–Kramer post hoc test. Full-size images of immunoblots are presented in Additional file 1: Fig. S11. f Expression of phospho-ASK1 (Thr-845) was significantly increased in the BO group (n = 4) and this increase was significantly blocked in the BO + V group (n = 5). ^*P < 0.05 by one-way ANOVA followed by the Tukey–Kramer post hoc test. Full-size images of immunoblots are presented in Additional file 1: Fig. S12. Data are presented as mean ± SD