Fig. 4
From: TMC4 is a novel chloride channel involved in high-concentration salt taste sensation
Licking behaviour of Tmc4 knock-out (KO) mice with five basic tastes. A, B Lick ratio of wild-type (WT) or Tmc4 KO mice for NaCl (A) and KCl (B) solutions (30, 100, 300, 500, and 700 mM) to water. C Attraction to NaCl solution (2, 20, 50, 100, and 200 mM) of mice treated with furosemide (50 mg/kg) and a low sodium diet. D Lick ratio for taste substance solutions to water: sucrose for sweet, a mixture of monosodium glutamate (MSG) and inosine monophosphate (IMP) for umami, citric acid for sour, denatonium for bitter. Data are expressed as the mean ± SEM. The asterisk (*) indicates statistical difference (p < 0.05). Significance was evaluated using two-way ANOVA (WT: n = 9, KO: n = 7)