Fig. 6

The effects of expiratory negative airway pressure (ENAP) on the systolic aortic blood pressure (SBP) and heart rate (HR) during fluvoxamine-induced cardiovascular collapse in each animal. In the presence of pharmacological adrenergic denervation, 10 mg/kg of fluvoxamine maleate decreased the SBP to < 40 mmHg within 4 animals (animals #1, #2, #4 and #5), whereas the SBP was kept > 40 mmHg in 1 animal (#3; not shown in the figure) during the observation period. When the SBP decreased to < 40 mmHg, the ENAP treatment was applied to animals #2 and #4 (ENAP-treated group, n = 2, right panels), whereas it was not used for animals #1 and #5 (Control group, n = 2, left panels). Gray bar indicates the period when the animals received the ENAP treatment. Note that the SBP was effectively elevated by the ENAP treatment during cardiovascular collapse (#2, #4) as well as at the recovery phase (#2); thus, the ENAP saved the lives of the animals in fatal cardiovascular collapse. C: Control value before the administration of fluvoxamine maleate