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Fig. 5 | The Journal of Physiological Sciences

Fig. 5

From: Anoctamin 1 antagonism potentiates conventional tocolytic-mediated relaxation of pregnant human uterine smooth muscle

Fig. 5

Terbutaline inhibits spontaneous transient inward currents (STICs) recorded from human primary uterine cultured cells. a Representative whole-cell recordings of STICs in response to terbutaline 10 µM. At holding voltages − 60 mV potential, the average current was − 359.8 ± 97 pA (events 251 ± 99, n = 5), compared to control − 385.2 ± 82 pA (events 247 ± 67, n = 6). b Representative whole-cell recordings of STICs in response to terbutaline 50 µM or 100 µM. With perfusion of terbutaline 50 µM at holding voltage − 60 mV, the average current was − 320 ± 69.5 pA (events 181 ± 45, n = 5). At terbutaline 100 µM, the average current was reduced to − 165.6 ± 44.1pA (events 108 ± 35, n = 6). c Bar graph depicting the effects of different concentrations of terbutaline on average current of STICs. At terbutaline 100 µM, the difference was statistically different from control (*p < 0.05)

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