Table 3 Pharmacological parameters of inhibitory effects of PGE2 and each EP receptor agonist on mean frequency and mean amplitude of GCs in the CM of rat middle colon
Mean frequency (% of basal) | Mean amplitude (% of basal) | |||||
|---|---|---|---|---|---|---|
IC50 (mol L−1) | nH | R2 | IC50 (mol L−1) | nH | R2 | |
PGE2 (endogenous agonist) | 4.58 × 10−8 | 0.739 | 0.966 | 2.36 × 10−8 | 0.749 | 0.969 |
ONO-DI-004 (EP1 agonist) | No inhibitory effect | No inhibitory effect | ||||
ONO-AE1-259 (EP2 agonist) | 9.57 × 10−9 | 1.000 | 0.786 | > 10−8 | - | - |
ONO-AE-248 (EP3 agonist) | No inhibitory effect | No inhibitory effect | ||||
ONO-AE1-329 (EP4 agonist) | 2.24 × 10−9 | 1.001 | 0.983 | > 10−8 | - | - |