Fig. 3

CCK positive neurons in each brain region of LETO and OLETF rats. Representative immunohistochemical images of the amygdala (a and b), hippocampus (c and d), and medial prefrontal cortex (e and f) of LETO (a, c, and e) and OLETF (b, d, and f) rats. High magnification images of the square area in each image are presented. Arrows indicate CCK positive neurons; arrows with L or S indicate large or small CCK positive neurons in the amygdala, respectively. Scale bars = 50 µm. The densities of CCK positive neurons in each region of LETO and OLETF rats (g). LA: lateral amygdala; BLA: basolateral amygdala; CA1–3: cornu ammonis area 1–3; DG: dentate gyrus; ACC: anterior cingulate cortex; PL: prelimbic cortex; IL: infralimbic cortex; CCK+: cholecystokinin positive. Values represent mean ± standard error of means. Statistically significant differences from LETO rat data are represented by asterisks: * p < 0.05, ** p < 0.01