Impact of delayed ventricular wall area ratio on pathophysiology of mechanical dyssynchrony: implication from single-ventricle physiology and 0D modeling

Table 2 Second-order polynomial models by response surface method

	β	p
Response variable: log₁₀BNP	(R² = 0.45)	< .001
Explanatory variable
QRS duration Z-score (QRSZ)	0.72	< .001
Area ratio of the delayed wall (AR_delayed)	− 0.122	0.32
(QRSZ − 4.56)²	− 0.17	0.24
(AR_delayed − 57.2)²	− 0.31	0.011
(QRSZ − 4.56) · (AR_delayed − 57.2)	0.09	0.41
Response variable: estEes	(R² = 0.32)	< .001
Explanatory variable
QRS duration Z-score (QRSZ)	− 0.64	< .001
Area ratio of the delayed wall (AR_delayed)	0.00	0.98
(QRSZ − 4.56)²	0.15	0.36
(AR_delayed − 57.2)²	0.16	0.19
(QRSZ − 4.56) · (AR_delayed − 57.2)	− 0.06	0.58

β, standardized coefficient; BNP, B-type natriuretic peptide; estEes, estimated ventricular elastance at end-systole; Constant terms 4.56 and 57.2 are means of QRS duration Z-score and the area ratio of the delayed wall in percentage, respectively

ISSN: 1880-6562