Fig. 6
Impact of the ratio of the delayed compartment and an activation delay on simulated hemodynamics. Tiled heat maps colored according to the change in maximal derivatives of ventricular pressure (ΔdP/dt max) relative to its baseline value (ΔT = 0), the amount of the reverse flow from the delayed to earlier activated compartment during systole (expressed in percentage of the baseline output), the difference in times to peak strain between earlier and delayed hemiglobal strain curves, and Rstrains on earlier hemiglobal strain (defined in main text) are shown in a. In b, their correlation is shown with the relative change in ventricular contractility (ΔEes). Gray dots represent a total of 361 simulated conditions; i.e., 19 conditions of an activation delay of ΔT from 0 to 90 ms every 5 ms multiplied by 19 conditions of the ratio of the delayed compartment from 5% to 95% every 5%. The correlation of ΔdP/dt max and reverse flow with ΔEes were heterogeneous. The gap between times to peak of earlier and delayed hemiglobal strain gave nonconsecutive change. The increase in Rstrains at earlier hemiglobal strain can provide a good prediction of reduced ventricular contractility. Purple curves indicate a 95% confidence ellipse; ρ, Spearman’s rank correlation coefficient