Cardiac specific transcription factor Csx/Nkx2.5 regulates transient-outward K+ channel expression in pluripotent P19 cell-derived cardiomyocytes

Table 1 Action potential parameters of P19CL6-derived cardiomyocytes and P19CL6-Csx-derived cardiomyocytes

	P19CL6		P19CL6-Csx
	Early stage (n = 17)	Late stage (n = 11)	Early stage (n = 17)	Late stage (n = 8)
Beating rate (bpm)	65.9 ± 21.2	73.3 ± 47.1	72.5 ± 29.2	80.6 ± 24.6
Maximal diastolic potential (mV)	‒ 54.8 ± 5.4	‒ 56.7 ± 8.2	‒ 64.2 ± 7.2*	‒ 59.4 ± 4.7
Maximal upstroke velocity (V s⁻¹)	3.2 ± 1.4	3.8 ± 1.9	3.3 ± 1.6	4.1 ± 1.6
APD₅₀ (ms)	77.4 ± 19.7	53.8 ± 28.1*	76.6 ± 27.5	48.4 ± 20.0^†

Each value was collected as an average of randomly assigned 10 consecutive action potentials from cells indicated in parentheses in number, and are shown as mean ± SD
APD₅₀ action potential durations measured at 50% repolarization
* p < 0.05 compared with P19CL6 cells in the early stage
^†p < 0.05 compared with P19CL6-Csx cells in the early stage

ISSN: 1880-6562