Fig. 12

Simulation of quick releases of the virtual sample during the isometric cycle in the TP + M model. The initial length L_init is equal to 90%L_max. The sample is quickly released to 95%L_init at 90 and 240 ms after the stimulus and is held at a new length until the end of the cycle. a–d Virtual sample length, force development, intracellular Ca²⁺ transient ([Ca²⁺]_i) and membrane potential in the simulation