Skip to main content

Table 1 Hemodynamics under anesthesia and plasma neurohumoral parameters in the remodeling study

From: Intracerebroventricular infusion of donepezil prevents cardiac remodeling and improves the prognosis of chronic heart failure rats

 

CST group (n = 13)

CDT group (n = 14)

P value

BW, g

428 ± 9

430 ± 7

NS

HW, g/kg

2.97 ± 0.05

2.77 ± 0.07

< 0.05

Infarct size, %

47 ± 1

48 ± 1

NS

MBP, mmHg

88 ± 2

83 ± 2

NS

HR, bpm

304 ± 8

309 ± 5

NS

CI, mL/min/kg

145 ± 11

181 ± 13

< 0.05

LV + dp/dtmax, mmHg/s

3116 ± 145

3699 ± 81

< 0.01

LV − dp/dtmax, mmHg/s

2682 ± 119

3108 ± 118

< 0.05

LVEDP, mmHg

28 ± 1

20 ± 2

< 0.01

RAP, mmHg

8 ± 1

5 ± 1

< 0.01

Plasma (pg/mL)

 Norepinephrine

1566 ± 217

741 ± 215

< 0.05

 Epinephrine

2248 ± 445

893 ± 233

< 0.05

 BNP

429 ± 27

359 ± 8

< 0.05

 AVP

724 ± 49

490 ± 43

< 0.01

 ANG II

138 ± 33

60 ± 10

< 0.05

  1. Values are means ± SEM. NS not significant. Hemodynamic parameters assessed by unpaired Student’s t-test. Plasma neurohumoral parameters assessed using a non-parametric Mann–Whitney U-test
  2. BW, body weight; HW, biventricular weight normalized by body weight; MBP, mean arterial pressure; HR, heart rate; CI, cardiac index (cardiac output/BW); LV + dp/dtmax, maximum positive dp/dt of left ventricular pressure; LV − dp/dtmax, maximum negative dp/dt of left ventricular pressure; LVEDP, left ventricular end-diastolic pressure; RAP, right atrial pressure. BNP, brain natriuretic peptide; AVP, arginine vasopressin; ANG II, angiotensin II
Back to article page

The Journal of Physiological Sciences

ISSN: 1880-6562

Contact us