Table 1 Properties of NCX1 stimulants
From: Cardiac Na+/Ca2+ exchange stimulators among cardioprotective drugs
NCX1 stimulants | Drug class | EC50 value, potential | Preparation |
|---|---|---|---|
Nicorandil | KATP channel opener Nitrate generator | EC50 15.0 μM (outward), 8.7 μM (inward) Approximately 60% enhancement (100 μM, outward and inward) | Guinea-pig ventricular myocytes [24] |
Pinacidil | Non-selective KATP channel opener | EC50 23.5 μM (outward), 23.0 μM (inward) Approximately 55% enhancement (100 μM, outward and inward) | Guinea-pig ventricular myocytes [27] |
SNP | NO donor | 34.3 ± 8.1% enhancement (1 mM, outward) | Guinea-pig ventricular myocytes [27] |
α-hANP | Peptide hormone | 46 ± 10% enhancement (100 nM, inward) | Rat Aorta vascular smooth muscle [12] |
Sildenafil | PDE5 inhibitor | Pinacidil-induced I NCX increase (outward, 10 μM pinacidil 16 ± 8.1%, + 10 μM sildenafil 48.5 ± 2.2% enhancement) | Guinea-pig ventricular myocytes [27] |
Flecainide | Class Ic antiarrhythmic drug | Approximately 60% enhancement (100 μM, outward and inward) | Guinea-pig ventricular myocytes [59] |
Dofetilide | Class III antiarrhythmic drug | EC 50 0.249 μM (outward), 0.149 μM (inward) Approximately 120% enhancement (1 μM, outward) | Rat Ventricular myocytes [65] |