Fig. 3

Glucose induces insulin secretion from islets in βNUCB2 KO mice to a lesser extent than in Cre mice. Basal insulin secretion from isolated islets under static incubation with 2.8 mM glucose was not significantly different between Cre and βNUCB2 KO mice. High glucose (8.3 mM) significantly increased insulin secretion from isolated islets of both Cre and βNUCB2 KO mice, and the increased level was significantly lower in βNUCB2 KO than Cre mice. n = 8 groups for 2.8 mM Cre mice and n = 6 groups for other. *P < 0.05, **P < 0.01 and ***P < 0.001